血管内近距离放射治疗剂量影响因素的研究  

Study of dose-influencing factors in endovascular brachytherapy

作　　者：苑淑渝[1] 戴光复[1] 刘寅[2] 高静[2] 徐志勇[1] 

机构地区：[1]中国医学科学院中国协和医科大学放射医学研究所,天津300192 [2]天津市胸科医院

出　　处：《中华放射医学与防护杂志》2004年第4期364-366,共3页Chinese Journal of Radiological Medicine and Protection

基　　金：国家自然科学基金资助项目 (3 0 170 2 3 3 )

摘　　要：目的　研究32 P球囊预防血管再狭窄的影响因素。方法　采用组织等效血管和热释光剂量学方法。结果　 2 5mm× 2 0mm空球囊内残留32 P对血管壁造成的剂量影响是 0 92Gy min。当球囊内导管偏离中心时 ,球囊外表面的吸收剂量将降低 2 0 %。气泡位置处的吸收剂量比球囊外表面平均吸收剂量低约 30 %。结论　32 P球囊表面轴向剂量分布较均匀 ,但径向吸收剂量随距离增加迅速减少。血管内近距离放射治疗有很好的临床应用前景。Objective To study the 32 P balloon beta dose-influencing factors in preventing endovascular restenosis. Methods The blood vessel wall was substituted by muscle equivalent material.Determination of the dose of the vessel wall was performed by thermoluminescence dosimetric method. Results When 32 P liquid remained in the empty balloon,the dose of the vessel wall was increased by 0.92 Gy/min. When the center catheter was closed to the balloon wall,the absorbed dose of the balloon surface decreased by 20%. When there were air bubbles in the balloon,the dose adjacent to air bubble lowered by 30% than the average absorbed dose of balloon surface. Conclusions The results show that the axisal absorbed dose of 32 P on balloon surface is uniform but the radial dose distribution is attenuated very rapidly with distance. The endovascular brachytherapy has good perspectives,but there are many problems to be solved for its clinical application.

关 键 词：血管 近距离 放射治疗 热释光 剂量学 

分 类 号：R815[医药卫生—放射医学]