肺心病合并糖尿病患者内皮素1、肿瘤坏死因子α、白介素6的变化及临床意义  

Changes of endothelin-1,tumor necrosis factor-α,and interleukin-6 in patients with chronic pulmonary heart disease complicating diabetes mellitus

作　　者：靳红[1] 袁涛[1] 

机构地区：[1]成都市第二人民医院干部科,成都610016

出　　处：《实用医院临床杂志》2004年第4期23-24,共2页Practical Journal of Clinical Medicine

摘　　要：目的　研究内皮素 1(ET 1)、肿瘤坏死因子α(TNF α)、白介素 6 (IL 6 )在肺心病合并糖尿病中的临床意义。方法　对肺心病合并糖尿病患者 32例 (其中肺心病代偿期合并糖尿病患者 16例 ,肺心病失代偿期合并糖尿病患者 16例 ) ,单纯肺心病患者 87例 (其中肺心病代偿期患者 38例 ,肺心病失代偿期患者 4 9例 ) ,单纯糖尿病患者 5 5例 ,及 70例正常对照组用放免法做ET 1、TNF α、IL 6的测定。结果　肺心病合并糖尿病组、单纯糖尿病组、及单纯肺心病组血浆ET 1、TNF α、IL 6均大于正常对照组 ,差异有显著性意义。肺心病合并糖尿病组血浆ET 1、TNF α、IL 6又明显大于单纯糖尿病组及单纯肺心病组 ,并且肺心病失代偿期合并糖尿病组又明显大于肺心病代偿期合并糖尿病组 ,差异均有显著性意义。结论　肺心病、糖尿病、特别是肺心病合并糖尿病中ET 1、TNF α、IL 6明显增高 ,说明ET 1、TNF α、ILObjective To investigate the clinical significance of changes in endothelin 1(ET 1), tumor necrosis factor α(TNF α), and interleukin 6(IL 6)inchronic pulmonary heart disease (CPHD) complicating diabetes mellitus (DM).Methods The serum concentration of ET 1,TNF α,IL 6 was measured by radioimmunoassay in 32 patients with CPHD complicating DM (with each 16 patients in compensated stage or decompensated stage), 87 patients with single CPHD (38 patients in compensated stage and 49 in decompensated stage), 55 patients with single DM, and 70 healthy subjects as control.Results The mean values of ET 1,TNF α,and IL 6 in patients with CPHD complicating DM, single DM or CPHD were significantly higher than those in controls. The mean values of ET 1,TNF α,and IL 6 were also higher in patients with CPHD complicating DM than those with single CPHD or DM, and so were in patients with compensated stage than decompensated stage of CPHD.Conclusion Serum ET 1,TNF α,and IL 6 levels are substantially increased in CPHD or DM patients especially for those with CPHD complicating DM, suggesting they are involved in the development of CPHD and DM

关 键 词：肺源性心脏病 糖尿病 内皮素1 肿瘤坏死因子Α 白介素6 

分 类 号：R541.5[医药卫生—心血管疾病] R587.1[医药卫生—内科学]