Effect　of　Combined　Norethisterone　Enantate　50mg　Monthly　Injectable　Contraceptive　on　Carbohydrate　Metabolism  

作　　者：孙丹利 沈康元 孟远翔 卢凤英 蒋海瑛 杨华 张美云 陈爱君 

出　　处：《Journal of Reproduction and Contraception》1994年第1期222-229,共8页生殖与避孕（英文版）

摘　　要：The effect on carbohydrate metabolism of using foe combined injectable contraceptive Norethisteron enantate 50mg/ Eslradiol valerate sing (NET-EN/ EV)for 12 months was studied in 22 healthy women, other 20 heallhJ' lromen Ivere recruited as the blank conlrol. Fasting plasma glucose, OGTT and plasma insull'n response ic glllCose ltiere measured in the follicular phase and luleal phase of pre-treatment c*1,cle, in foe bileal phase of the 3rd, 6th and 12th monlh during foe treatment period, and l'n foe post--trealmenl c.l'cle. In foe treatment group, no deference was observed infasling glucose concenlrations as compared Ivith those of based'ne values and with the conlrol group,it'hile the glucose concenlralions Of Zh afler glucose load in the 3rd month reduced significantly as compared it)ith those if baseline (P< 0.01). The AUC Of glucose cated a significant decrease in the 3rd and 6th months (P< 0.05 and P< 0.01,respectively). Because all gluCose concentrations l'n OGTT were withl'n the normal range and the similar chang$s occurred in the control group, the reduction seems to be Of little pathological significance. Plasma insulin levels Of both fasting and Zh afler glucose load,it)ere significantly decreased in the 12th treatment month (P< 0.01 and P< 0.001,respectively) andpost-trealment cycle (PM 0.0i and P< 0.00i, respectively). The AUC of insulin showed a significant reduction, but similar changes were found in the control group.It is concluded that there is no significanl effect on carbohydrate metabolismfollolting foe treatmenl of NET-EN 50mg/ EV 5mg for One year.The effect on carbohydrate metabolism of using foe combined injectable contraceptive Norethisteron enantate 50mg/ Eslradiol valerate sing (NET-EN/ EV)for 12 months was studied in 22 healthy women, other 20 heallhJ' lromen Ivere recruited as the blank conlrol. Fasting plasma glucose, OGTT and plasma insull'n response ic glllCose ltiere measured in the follicular phase and luleal phase of pre-treatment c*1,cle, in foe bileal phase of the 3rd, 6th and 12th monlh during foe treatment period, and l'n foe post--trealmenl c.l'cle. In foe treatment group, no deference was observed infasling glucose concenlrations as compared Ivith those of based'ne values and with the conlrol group,it'hile the glucose concenlralions Of Zh afler glucose load in the 3rd month reduced significantly as compared it)ith those if baseline (P< 0.01). The AUC Of glucose cated a significant decrease in the 3rd and 6th months (P< 0.05 and P< 0.01,respectively). Because all gluCose concentrations l'n OGTT were withl'n the normal range and the similar chang$s occurred in the control group, the reduction seems to be Of little pathological significance. Plasma insulin levels Of both fasting and Zh afler glucose load,it)ere significantly decreased in the 12th treatment month (P< 0.01 and P< 0.001,respectively) andpost-trealment cycle (PM 0.0i and P< 0.00i, respectively). The AUC of insulin showed a significant reduction, but similar changes were found in the control group.It is concluded that there is no significanl effect on carbohydrate metabolismfollolting foe treatmenl of NET-EN 50mg/ EV 5mg for One year.

关 键 词：Glucose Insulin OGTT AUC NET-EN 50mg/ EV 5mg 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]