In Vitro Skin Permeation of Osthol from Hydro-Alcoholic Gel Formulations  

In Vitro Skin Permeation of Osthol from Hydro-Alcohofic Gel Formulations

作　　者：YUANZhen-ting DINGPing-tian LuBo CHENDa-wei 

机构地区：[1]ShenyangPharmaceuticalUniversity,Shenyang110016,China [2]AnshanTanggangziHospital,Anshan114000,China

出　　处：《Journal of Chinese Pharmaceutical Sciences》2004年第3期176-179,共4页中国药学（英文版）

摘　　要：Aim To evaluate the in vitro percutaneous absorption behavior of osthol from a series of hydro-alcoholic gel formulations containing three penetration enhancers through excised human skin (stratum cormeum and epidermis,SCE). Methods Excised human skin was mounted in Franz-type diffusion cells. The samples withdrawn from the receptor cell were analyzed for osthol content by high-performance liquid chromatography (HPLC). Results The enhancers azone,menthol and chenopodium increased the osthol percutaneous steady-state fluxes 3.12, 2.00 and 1.25 times those of the enhancer-free formulations (controls), separately. Conclusions The main enhancement mechanism of the skin penetration enhancers azone, menthol and chenopodium is to destroy the barrier function of stratum corneum, reducing the resistance of drug transport through the skin and increasing the diffusion coefficients of osthol.Aim To evaluate the in vitro percutaneous absorption behavior of osthol from a series of hydro-alcoholic gel formulations containing three penetration enhancers through excised human skin (stratum cormeum and epidermis,SCE). Methods Excised human skin was mounted in Franz-type diffusion cells. The samples withdrawn from the receptor cell were analyzed for osthol content by high-performance liquid chromatography (HPLC). Results The enhancers azone, menthol and chenopodium increased the osthol percutaneous steady-state fluxes 3.12, 2.00 and 1.25 times those of the enhancer-free formulations (controls), separately. Conclusions The main enhancement mechanism of the skin penetration enhancers azone, menthol and chenopodium is to destroy the barrier fimction of stratum corneum, reducing the resistance of drug transport through the skin and increasing the diffusion coefficients of osthol.

关 键 词：OSTHOL percutaneous absorption GEL penetration enhancers 

分 类 号：R943[医药卫生—药剂学]