Association between β2-adrenergic Receptor Genetic Polymorphisms and Nocturnal Asthmatic Patients of Chinese Han Nationality  

作　　者：YINKai-sheng QIUYu-ying ZHANGXi-long 

机构地区：[1]DepartmemtofRespiratotyMedicine,theFirstAffliatedHospitalofNanjingMedicalUniversity,Nanjing210029,P.R.China

出　　处：《Journal of Nanjing Medical University》2004年第5期235-238,共4页南京医科大学学报（英文版）

摘　　要：Objective: To analyze the association between β2-adrenergic receptor (β2-AR)genetic polymorphisms and nocturnal asthmatic patients of Chinese Han nationality. Methods: Polymerase chain reaction-allele specific oligonucleotide hybridization assay was used to determine 16 and 27 locus alleles of β2-AR genetic polymorphisms in 25 nocturnal asthmatic patients( NA group). 22 nonnocturnal asthmatic patients (NNA group) and 72 healthy people ( control group). All subjects were from Chinese Han nationality. Results. The distribution frequency of genotype Arg/Arg, Arg/Gly, and Gly/Gly at β2-AR 16 loci was 12%, 16% and 72% in NA group; and was 27%, 41% and 32% in NNA group. There was significant increase in the frequency of genotype Gly/Gly and allele Gly in NA group, compared with NNA group(P<0.01). However, there was no significant difference in the frequency of genotype Gly/Gly and allele Gly in NNA group, compared with control group. No significance in the frequency of the genotypes and alleles of β2-AR27 loci among the three groups(P>0.05). Conclusion: The Gly16 polymorphism of β2-AR is overrepresented in nocturnal asthmatic patients, correlated with nocturnal asthma and therefore appears to be an important genetic factor in the expression of this asthmatic phenotype.

关 键 词：β2-肾上腺素 受体 遗传多态性 夜间哮喘 中国 汉族 Β2-AR 

分 类 号：R562.25[医药卫生—呼吸系统]