两头尖的化学成分研究(I)  

Studies on the Chemical Constituents of the Rhizoma of Anemone raddeana Regel

作　　者：夏忠庭[1] 刘大有[1] 王晓颖[1] 刘科峰[1] 张培成[2] 

机构地区：[1]长春中医学院药学院,长春130021 [2]中国医学科学院北京药物研究所,北京100050

出　　处：《化学学报》2004年第19期1935-1940,共6页Acta Chimica Sinica

基　　金：国家科技部 1 0 35工程 (No.96 90 1 0 1 89);吉林省科技厅 (No.2 0 0 2 0 50 3 1 4 )资助项目

摘　　要：采用硅胶柱色谱和高效液相色谱等方法 ,对两头尖的化学成分进行了研究 ,从中分离得到两个化合物 ,经化学及IR ,ESI MS ,1HNMR ,13 CNMR ,DEPT ,HMQC ,HMBC ,GCOSY ,TOCSY等谱学分析鉴定其结构分别为 :3 O α L arabinopyranosyl( 1→ 3 ) α L rhamnopyranosyl( 1→ 2 ) [β D glucopyranosyl( 1→ 4) ] α L arabinopyranosyloleanolicacid 2 8 O α L rhamnopyranosyl( 1→ 4) β D glucopyranosyl( 1→ 6) β D glucopyranoside ( 1) ,3 O β D glucopyranosyl( 1→ 4) β D glucopyranosyl( 1→3 ) α L rhamnopyranosyl( 1→ 2 ) α L arabinopyranosyloleanolicacid 2 8 O α L rhamnopyranosyl( 1→ 4) β D glucopyranosyl( 1→ 6) β D glucopyranoside ( 2 ) ,该两个化合物为新化合物 ,分别命名为 :多被银莲花皂苷 16(Raddeanoside 16)和多被银莲花皂苷 17(Raddeanoside 17) .Two new triterpenoid saponins, raddeanoside 16 and raddeanoside 17 were isolated from the ethanolic extract of the rhizome of Anemone raddeana Regel. Their structures were elucidated as 3-O-alpha-L-arabinopyranosyl(1-->3)-alpha-L-rhamnopyranosyl(1-->2)-beta-D-glucopyranosyl(1-->4)1-alpha-L-arabinopyranosyl oleanolic acid 28-O-alpha-L-rhanmopyranosyl(1-->4)-beta-D-glucopyranosyl (1-->6)-beta-D-glucopyranoside (1) and 3-O-beta-D-glucopyranosyl(1-->4)-beta-D-glucopyranosyl (1-->3)-alpha-L-rhamnopyranosyl (1-->2)-alpha-L-arabinopyranosyl oleanolic acid 28-O-alpha-L-rhanmopyranosyl(1-->4)-beta-D-glucopyranosyl(1-->6)-beta-D-glucopyranoside (2) by 1D and 2D NMR spectroscopic methods, including DEPT, HMQC, HMBC, GCOSY and TOCSY experiments, respectively.

关 键 词：两头尖 化学成分 硅胶柱色谱 高效液相色谱 分离 结构鉴定 多被银莲花皂苷16 多被银莲花皂苷17 

分 类 号：O629[理学—有机化学] O657.7[理学—化学]