心房纤颤患者血液流变性的变化特点及降粘治疗的意义  

Characteristic of Blood Rheology in Patients with Atrial Fibrillation and the Significance of Lowering Blood Viscosity Treatment

作　　者：张利华[1] 曾佑平[1] 肖俊平[1] 

机构地区：[1]中国人民解放军第四军医大学唐都医院心脏内科,邮政编码西安710038

出　　处：《微循环学杂志》2004年第4期39-40,共2页Chinese Journal of Microcirculation

摘　　要：目的 :探讨心房纤颤患者血液流变性的变化特点及降低血粘度治疗的有效性。方法 :选心房纤颤患者 78例 ,其中持续性心房纤颤( >3月 ) 3 8例 ,阵发性心房纤颤 ( <3月 ) 40例 ,均口服巴米尔 (肠溶阿司匹林 )片 10 0mg和静脉滴注舒血宁注射液 2 0ml治疗 ,每日一次 ,共 2周。检测治疗前后血液流变学各参数。结果 :持续性心房纤颤组全血粘度、血浆粘度、红细胞压积、血小板粘附率和纤维蛋白原均明显高于阵发性心房纤颤组 (P <0 .0 5 ) ;经口服巴米尔片和静脉滴注舒血宁注射液治疗后 ,两组上述血流变学各参数较治疗前均有显著或非常显著性降低 (P <0 .0 5～ 0 .0 1)。结论 :心房纤颤患者易合并高血粘状态 。Objective: To study the characteristic of blood rheology in patients with atrial fibrillation (AF) and the significance of lowering blood viscosity treatment.Method: 78 patients with sustained ( n =38, more than 3 months) or paroxysmal ( n =40, less than 3 months) AF were selected, and blood rheology data were determined before and after oral administration of asprin 100 mg perday and venous transfusion extract of ginkgo biloba leaf 20 ml perday.Results: The data of blood viscosity, plasma viscosity, hematocrit, platelet adhesion rate and fibrinogen in patients with sustained AF are all significantly higher than in patients with paroxysmal AF; After oral administration of asprin and venous transfusion extract of ginkgo biloba leaf, the data in patients with sustained AF are all significantly lowered (compared with those before treatment, P <0.01), and the data in patients with paroxysmal AF are also significantly lowered( P <0.05). Conclusion: The patients with AF are easy to complicate blood hyperviscosity, especially in those with sustained AF. Oral administration of asprin and venous transfusion extract of ginkgo biloba leaf can steadily reduce the data of blood viscosity in patients with AF.

关 键 词：心房纤颤 血液流变性 变化特点 降粘治疗 

分 类 号：R541.75[医药卫生—心血管疾病]