清化消瘀方对Ⅱ型糖尿病合并高脂血症患者糖氧化修饰过程的影响  

EFFECTS OF QINGHUAXIAOYU PRESCRIPTION ON GLYCOSYLATED AND OXIDIZED MODIFIED PROCESS OF PATIENTS WITH DIABETICS ⅡCOMBINED HYPERLIPIDEMIA

作　　者：张炜宁 曾庆明 周晓 陈旭 吴智兵[2] 

机构地区：[1]深圳市福田区中医院,深圳518034 [2]广州中医药大学,广州510405

出　　处：《中国中医药科技》2004年第6期325-326,共2页Chinese Journal of Traditional Medical Science and Technology

基　　金：广东省中医药管理局科研基金项目No.10 1111

摘　　要：目的 :观察清化消瘀方对Ⅱ型糖尿病合并高脂血症患者糖氧化修饰过程的影响。方法 :72例Ⅱ型糖尿病合并高血脂症患者随机分为两组 ,对照组予西药常规治疗方案 (但禁用抗氧化剂 ) ,治疗组在对照组基础上加用清化消瘀方 ,疗程 4周 ,治疗前后测定血浆Gly -LDL、Ox -LDL、Gly -Ox -LDL。结果 :治疗组、对照组治疗前与正常对照组比较血浆Gly -LDL、Ox -LDL、Gly-Ox -LDL均明显升高 (P <0 0 1) ,而治疗后治疗组Gly -LDL、Ox -LDL、Gly-Ox -LDL均明显降低 (P <0 0 1) ,与正常对照组比较差异无显著性意义(P >0 0 5 )。结论 :Ⅱ型糖尿病合并高脂血症患者由于糖化修饰过程 ,导致晚糖化终产物含量增高 ,清化消瘀方能阻断这一进程 。Objective:To observe the effect of qinghuaxiaoyu prescripition on glycosylated and oxidized modified process in type Ⅱ diabetics combined hyperlipidemia.Methods:72 patients were randomly divided into two groups including qinghuxiaoyu treated group and western medicine control group.The level of Gly-LDL、Ox-LDL、Gly-Ox-LDL in plasma of patients were tested simultaneously before and after treatment.Results:The level of Gly-LDL、Ox-LDL、Gly-Ox-LDL in plasma of patients were significantly higher than those in normal group.After treated with qinghuxiaoyu prescription the level of Gly-LDL、Ox-LDL、Gly-Ox-LDL in plasma of patients were significantly lower than those in control group.Conclusion:qinghuxiaoyu could repress the glycosylated and oxidized modified process in patients with type Ⅱ diabetics combined hyperlipidemia.

关 键 词：清化消瘀方 Ⅱ型糖尿病 高脂血症 糖氧化修饰过程 中医药疗法 

分 类 号：R259.8[医药卫生—中西医结合]