氯诺昔康用于烧伤患者切痂植皮术后镇痛的效果观察  

Observation of Postoperative Analgesia Effects with Lornoxicam on Burned Patient s Undergoing Burn Wound Excision and Skin Grafting

作　　者：张娟[1] 郑永辉[1] 黄绍农[1] 

机构地区：[1]广东省深圳市第二人民医院麻醉科,518029

出　　处：《中国误诊学杂志》2004年第9期1406-1408,共3页Chinese Journal of Misdiagnostics

摘　　要：目的 :评价氯诺昔康用于烧伤患者切痂植皮术后持续静脉镇痛的镇痛效果和副作用。方法 :90例中、重度烧伤患者 ,择期在全麻下行全身多处烧伤切痂植皮手术 ,术后将患者随机分为 3组。芬太尼组 (n=30 ) ,使用芬太尼 1 mg+氟哌啶 3mg+生理盐水至总量 1 0 0 ml持续静脉输注。氯诺昔康组 (n=30 ) ,使用氯诺昔康 32 mg+芬太尼 0 .5 mg+氟哌啶 3mg+生理盐水至总量 1 0 0 ml持续静脉输注。曲马多组 (n=30 ) ,使用曲马多 5 0 0 mg+芬太尼 0 .5 mg+氟哌啶 3mg+生理盐水至总量 1 0 0 ml持续静脉输注。 3组持续输注速率为 2 ml/ h。观察术后镇痛 2 h、4 h和 1 2 h的镇痛效果和副作用。结果 :氯诺昔康组和芬太尼组在术后 2 h和 4 h的镇痛效果优于曲马多组 (P<0 .0 1 ) ;芬太尼组在术后 2 h、4 h和1 2 h的呼吸次数和脉搏血氧饱和度值低于氯诺昔康组和曲马多组 (P<0 .0 5 ) ;曲马多组术后 2 h、4 h的恶心、呕吐发生率高于氯诺昔康组和芬太尼组 (P<0 .0 1 )。结论 :氯诺昔康的镇痛效果优 ,副作用少 。Objective:To assess the analgesia effects and side effects of pos toperative analgesia with Lornoxicam on burned patients.Methods:90 burned pati ents, scheduled for burn wound excision and skin grafting, were randomly divided into Group Fentanyl, group Lornoxicam and group Tramadol . In group Fentanyl(n=30), fentanyl 1mg+droperidol 3mg+0.9% saline to totally 100ml we re infused, in Group Lornoxicam(n=30), lornoxicam32mg+fentanyl0. 5 mg+droperidol 3 mg+0.9% saline to totally 100ml were infused, and in Group Tra madol(n=30),tramadol 500 mg+fentanyl0.5 mg+ droperidol 3 mg+ 0.9 % saline to totally 100 ml were infused. The rate of infusion was 2 ml/L. Analgesia effects and side effects at 2h, 4h and 12h were observed and recorded. Results:Analgesia effects in Group Fentanyl and group Lornoxicam at 2h and 4h were s ignificantly better than that in group T(P<0.01). The values of breathing frequency and pulse oximetry in group Fentanyl at 2h, 4h and 12h were significantly lower than that in group L and group T (P<0.05). The rate of nausea and vomiting in group Tramadol at 2h and 4h were significantly higher than that in group Fentanyl and group Lornoxicam (P<0.01). Conclusion:The study suggested that Lornoxicam had a better analgesia effect and lower side effect. lornoxicam was suitable for postoperative analgesia on bu rned patients.

关 键 词：烧伤/外科学 疼痛 手术后 吡罗昔康/类似物和衍生物 吡罗昔康/治疗应用 芬太尼/治疗应用 曲马朵/治疗应用 

分 类 号：R644[医药卫生—外科学]