2-(对氯苯基)吡咯-3-腈类化合物的合成与杀虫活性  

Synthesis and insecticidal activity of 2- (p-chlorophenyl) pyrrole-3-carbonitriles

作　　者：徐尚成[1] 万琴[2] 倪珏萍[2] 俞幼芬[2] 许志专[2] 王晓军[2] 蒋木庚[1] 

机构地区：[1]南京农业大学理学院,江苏南京210095 [2]江苏省农药研究所,江苏南京210036

出　　处：《南京农业大学学报》2004年第4期110-113,共4页Journal of Nanjing Agricultural University

基　　金：国家"十五"农药科技攻关计划专题 (2 0 0 4BA3 0 8A2 2 2 )

摘　　要：以α对氯苯基甘氨酸为起始原料 ,经N甲酰化后 ,与 2氯丙烯腈进行 1,3偶极环化加成反应 ,得到中间体 2(对氯苯基 )吡咯 3腈 ;该中间体经吡咯环上的Vilsmeier甲酰化后 ,与伯胺R1NH2 进行加成反应及进一步的溴化 ,合成了 9个 2 (对氯苯基 )吡咯 3腈类新化合物。化合物结构经MS和1HNMR分析确认。初步的生物测定结果表明 ,部分化合物显示了良好的杀虫活性。The α- (p-chlorophenyl) glycine was subjected to N-formylation, and then to 1, 3-dipolarcycloaddition with 2-chloroacrylonitrile, giving 2- (p-chlorophenyl) pyrrole-3-carbonitrile. The pyrrole-3-carbonitrile went through Vilsmeier formylation at pyrrole, and the resulting product reacted with primary amines R1NH 2, forming 9 novel 2- (p-chlorophenyl) pyrrole-3-carbonitrile compounds. Their structures were confirmed via MS and 1H NMR. Preliminary biological activity evaluation showed that some of them exhibited good insecticidal activities.

关 键 词：芳基吡咯 合成 波谱分析 杀虫活性 

分 类 号：O626.13[理学—有机化学] S482.3[理学—化学]