小剂量米非司酮周期疗法治疗子宫肌瘤  

Hysteromyoma be treated periodically by little dose Ru486

作　　者：胡晓玲[1] 朱晓云[2] 庄建基[2] 肖帆[1] 李美芳[2] 

机构地区：[1]井冈山学院,江西吉安343000 [2]井冈山学院附属医院,江西吉安343000

出　　处：《井冈山医专学报》2004年第6期8-9,共2页Journal of Jinggangshan Medical College

摘　　要：目的观察小剂量米非司酮周期疗法治疗子宫肌瘤的疗效和对月经的影响。方法将49例子宫肌瘤分两组进行米非司酮周期治疗。米非司酮(Ru486)联合甲基睾丸素,简称MR组;单纯米非司酮,简称OR组。于治疗前后行B超测量子宫和子宫肌瘤的体积,并记录患者的临床表现。结果1个疗程后两组子宫及子宫肌瘤体积明显缩小,MR组肌瘤缩小42.73%±2.46%(P<0.001);OR组肌瘤体积缩小41.10%±2.50%(P<0.001),两组之间差异无显著性。治疗期间MR组无闭经36.20%;OR组无闭经32.69%。月经量明显减少、痛经缓解。结论12.5mg米非司酮周期疗法治疗子宫肌瘤有效,闭经减少,副作用减轻;加雄激素疗效无差异性,但对减少月经量和改善贫血症状有利。Objective:To observe the effect that the little dose Ru486 treats the Hysteromyoma and the tomenstrual infection.Methods:49 cases diveided 2 groups:Ru486 adding Methyltestosterone(MR); Only Ru486(OR).uterus and tumour examined by B ultrasound, clilinc sympotom noted.Results:One period of treatment,uterus and tumour obviously shorten,MR(42.73%±2.46%,P < 0.001),OR(41.10%±2.50%,P < 0.001).MR(36.20%),OR(32.69%)have not amennorrhea during treatment.Conclusion:It is effective with 12.5mg Ru486 periodically treats hysteromyoma and can reduce amennorrhea and side-effect.

关 键 词：米非司酮 周期疗法 子宫肌瘤 甲基睾丸素 闭经 

分 类 号：R711.7[医药卫生—妇产科学]