内毒素作用中的蛋白质和信号通路  

Proteins and signaling pathway in endotoxic effect

作　　者：秦玉新[1] 张庆柱[1] 

机构地区：[1]山东大学药学院药理学教研室,济南250012

出　　处：《中国药理学通报》2003年第12期1336-1339,共4页Chinese Pharmacological Bulletin

基　　金：山东大学博士启动基金资助No 90 87

摘　　要：综述内毒素作用中有关的蛋白及其传导通路。脂多糖结合蛋白 (LBP)可以结合内毒素并把它传递给受体 ,如CD14和CD11/CD18。Toll样受体 (TLRs)的功能与信号向胞内传递有密切的关系 ,清道夫受体则与肝脏清除内毒素的功能有关。胞内信号转导涉及多种途径 。This article reviews the proteins and transduction pat hw ay in endotoxic action. Lipopolysaccharide-binding protein(LBP) binds and trans ports the LPS to its receptors, which include CD14 and CD11/CD18. Toll-like rec eptors(TLRs) is closely associated with transducting the signals into cytoplasm. Scavenger receptors are related to hepatic clearance on endotoxin .The intracel lular signal transduction is involved in several paths which finally leads to t he release of cytokines.

关 键 词：内毒素 ToⅡ样受体 LBP CDL4 CD11/CDl8 信号转导 

分 类 号：R341[医药卫生—基础医学]