青辛速释贴中靛蓝透皮渗透研究  

Percutaneous absorption of indigotin from Qingxinsushitie

作　　者：郑国燊[1] 罗光亮 

机构地区：[1]暨南大学医学院第六附属医院江门市五邑中医院,江门529031 [2]深圳市福田区中医院,深圳518034

出　　处：《中南药学》2003年第5期273-275,共3页Central South Pharmacy

基　　金：广东省中医药管理局立项课题(NO:099628)

摘　　要：目的研究青辛速释贴中靛蓝经皮渗透特性。方法采用改良Franz扩散池法以高效液相色谱法检测透过的靛蓝。结果 5 h、10 h、15 h、25 h、35 h、50 h靛蓝的累积透过量分别为23.51 μg·cm-2、30.32 μg·cm-2、37.60μg·cm-2、46.01μg·cm-2、57.60 μg·cm-2、66.68μg·cm-2,累积透过百分率14.10％、18.18％、22.55％、27.59％、34.54％、40.00％,经皮渗透符合一级速率过程,释放速率为0.998 μg·cm-2·h-1。结论青辛速释贴可加快靛蓝的释放,达到速释的目的,该实验在一定程度上反映出青辛速释贴透皮吸收的真实情况。OBJECTIVE To study the percutaneous absorption of indigotin from Qingxinsushitic (QST) METHODS The permeated indigotin was determined by spextrophotometry with improved Franz diffusing cells. RESULTS The percutaneous absorption amount at 5 h, 10 h, 15 h, 25 h, 35 h, and 50 h were 23. 51 μg ·cm -2, 30. 32 μg · cm-2 37. 60 μg · cm -2, 46. 01 μg · cm -2 , 57. 60 μg · cm -2 , and 66. 68 μg · cm -2 respectively. The percutaneous absorption rates were 14. 10%, 18.18%, 22.55%, 27.59%, 34.54%, and 40. 00%. CONCLUSIONS Indigotin in QST could penetrate through the skin and be absorbed. QST is suitable for skin administration through skins.

关 键 词：青辛速释贴 经皮渗透 靛蓝 改良Franz扩散池 

分 类 号：R944.9[医药卫生—药剂学]