梅毒、红斑狼疮和皮肌炎患者抗磷脂抗体检测  

Detection of serum antiphospholipid antibodies in the patients with syphilis, systematic lupus erythematosus and dermatomyositis

作　　者：郭哲[1] 赵玉铭[1] 王雅坤[1] 赖鑫[1] 陈洪铎[1] 

机构地区：[1]中国医科大学附属第一医院皮肤科

出　　处：《临床皮肤科杂志》2003年第12期709-711,共3页Journal of Clinical Dermatology

摘　　要：目的:探讨抗磷脂抗体与梅毒、系统性红斑狼疮SLE和皮肌炎DM的关系。方法:应用酶联免疫吸附试验检测16例梅毒患者、32例SLE患者和11例皮肌炎患者血清中的抗磷脂抗体。结果:①梅毒患者抗磷脂抗体的吸光度A值IgG型抗磷脂酰胆碱抗体aPC除外和IgM型阳性率抗磷脂酸抗体aPA除外与正常人相比显著升高,IgG型抗磷脂抗体阳性率只有抗心磷脂抗体aCL和抗磷脂酸抗体aPA,与正常人相比显著升高;②SLE患者抗磷脂抗体的A值和阳性率IgG型抗磷脂酰乙醇胺抗体aPE和IgM型抗磷脂酰肌醇抗体aPI除外与正常人相比显著升高;③DM患者抗磷脂抗体的A值IgG型抗磷脂酰乙醇胺抗体aPE除外与正常人相比显著升高。④梅毒和SLE患者总阳性率与正常人相比显著升高。结论:自身免疫性疾病患者的抗磷脂抗体与感染时有所不同;抗磷脂抗体虽然存在于多种自身免疫性疾病中,但以SLE的阳性率最高。Objective: To investigate the relationships of antiphospholipid (APL) antibodies with syphilis, systematic lupus erythematosus (SLE) and dermatomyositis (DM). Methods: Serum APL antibodies were detected by enzyme linked immunosorbent assay in 16 cases of syphilis, 32 cases of SLE and 11cases of DM. Results: (1) The levels of IgG APL (except aPC) and IgM APL (except aPA) were significantly higher in the patients with syphilis than that in normal controls. The positivity rate of aCL and aPA of IgG APL was also significantly higher in these patients than that in normal controls; (2) The values and the positivity rate of APL antibodies (except aPE of IgG and aPI of IgM) were significantly higher in the patients with systematic lupus erythematosus than that in normal controls; (3) The values of APL antibodies (except aPE of IgG) were significantly higher in the patients with dermatomyositis than that in normal controls. Conclusions: There are differences in the types of APL antibodies between auto- immune diseases and infectious diseases. The positivity rate of serum APL antibodies in SLE is the highest among auto- immune diseases.

关 键 词：梅毒 红斑狼疮 系统性 皮肌炎 抗磷脂抗体 

分 类 号：R759.1[医药卫生—皮肤病学与性病学] R593.241[医药卫生—临床医学]