单纯性肥胖儿童最大有氧能力与ACE基因I/D多态的关联研究  

Association study between ACE gene I/D polymorphism and simple obese children's maximal aerobic capacity

作　　者：何子红[1] 马力宏[2] 

机构地区：[1]天津体育学院研究生部,天津300381 [2]天津体育学院实验中心,天津300381

出　　处：《体育科学》2002年第1期94-97,共4页China Sport Science

基　　金：国家教育部留学回国人员启动资金

摘　　要：研究目的:探讨单纯性肥胖儿童与正常体重儿童最大有氧能力的差异,并究其差异是否与ACE基因I/D多态性关联。研究方法:以自行建立的无任何损伤的口腔上皮细胞法提取DNA,进行基因多态性分析。研究结果:单纯性肥胖儿童最大有氧能力低于正常体重儿童(P<0.01),但这种差异与心室结构不相关。推测,中枢机制不是青春前期儿童最大有氧能力差异的主要限制因素。血管紧张素转化酶基因插入/缺失遗传多态与青春前期儿童最大有氧能力不关联,但与其室容积关联。The purpose of this study is to investigate the difference between simple obese children and normal weight children in maximal aerobic capacity and the molecule basis.Method:The gene polymorphism was analyzed by the DNA extracted method from epithelia in mouthwash.The results showed:VO_2max is significantly lower in obese children than normal weight children,but which is no relationship with left ventricular structure.It is suggested that central mechanism is not vital factor in pre-puberty children.Association had not been found between ACE gene I/D polymorphism and VO_2max,but the polymorphism is associated with V derived from ECG.

关 键 词：运动医学 单纯性肥胖儿童 最大有氧能力 ACE基因 心室结构 关联研究 

分 类 号：G804.7[文化科学—运动人体科学]