硒镉对培养心肌细胞生物电活动的影响  

Synergetic effect of selenium and cadmium on the electrophysiological properties of myocardial cells of the rat

作　　者：段耀奎[1] 曹文华[2] 贾政军[3] 李金国[1] 赵晓光[1] 

机构地区：[1]泰山医学院生理学教研室,山东泰安271000 [2]泰山医学院附属医院内科,山东泰安271000 [3]泰安市中心医院,山东泰安271000

出　　处：《泰山医学院学报》2003年第4期316-318,共3页Journal of Taishan Medical College

基　　金：山东省教育厅科研发展计划课题 (J97K10 )

摘　　要：目的　进一步研究微量元素硒 (Se)镉 (Cd)对心肌细胞的协同性影响。方法　用细胞内微电极技术 ,分别测定了正常对照、高Cd、高Se伴高Cd条件下培养的大鼠心肌细胞生物电活动的改变。结果　高Cd状态下培养的心肌细胞 ,其静息电位 (RP)减小、动作电位幅度 (APA)降低、动作电位复极 5 0 %时的时程 (APD50 )缩短 ,而高Cd伴高Se条件下培养的心肌细胞 ,RP、APA、APD50 与对照组相比差异无显著性意义。提示 :高Cd对培养的心肌细胞有损害作用 ;Objective: To explore the synergetic effect of selenium and cadmium on the electrophysiological properties of myocardial cells of the rat Methods: Intracellar microelectrode technique was used to study the electrophysiological changes of the myocardial cells cultured at different selenium and cadmium concentrations Results: When myocardial cells were cultured at high cadmium concentrations, the RP and APA decreased and APD 50 was shortened However, when selenium was added to the experimental system, these electrophysiological parameters had no significant changes compared with those in the control Conclusion: These results show that cadmium can injure the cultured myocardial cells and selenium plays an important role in preventing the cells from injury

关 键 词：硒 镉 心肌细胞 电生理 

分 类 号：R542.3[医药卫生—心血管疾病]