Synthesis of Analogues of the Antitumor (1→6)-Branched (1→3)-Glucohexaose  

作　　者：曾佑林 张建军 孔繁祚 

机构地区：[1]Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China

出　　处：《Chinese Journal of Chemistry》2004年第5期460-466,共7页中国化学（英文版）

基　　金：Project supported by Chinese Academy of Sciences (No. KZCX3-J-08) and the National Science Foundation of China (Nos. 30070185 and 39970964).

摘　　要：b-D-Glcp-(13)-[b-D-Glcp-(16)-]a-D-Manp-(13)-b-D-Glcp-(13)-[b-D-Glcp-(16)-]D-Glcp (18) and b-D-Glcp-(13)-[b-D-Glcp-(16)-]a-D-Manp-(13)-b-D-Glcp-(13)-[b-D-Glcp-(16)-]b-D-Glcp-D-(13)-Glcp-1OMe (29) were synthesized as the analogues of the immunomodulator b-D-Glcp-(13)-[b-D-Glcp- (16)-]a-D-Glcp-(13)-b-D-Glcp-(13)-[b-D-Glcp-(16)-]D-Glcp through coupling of trisaccharide donors 9 with trisaccharide acceptor 16 and tetrasaccharide acceptor 27 followed by deprotection, respectively.b-D-Glcp-(13)-[b-D-Glcp-(16)-]a-D-Manp-(13)-b-D-Glcp-(13)-[b-D-Glcp-(16)-]D-Glcp (18) and b-D-Glcp-(13)-[b-D-Glcp-(16)-]a-D-Manp-(13)-b-D-Glcp-(13)-[b-D-Glcp-(16)-]b-D-Glcp-D-(13)-Glcp-1OMe (29) were synthesized as the analogues of the immunomodulator b-D-Glcp-(13)-[b-D-Glcp- (16)-]a-D-Glcp-(13)-b-D-Glcp-(13)-[b-D-Glcp-(16)-]D-Glcp through coupling of trisaccharide donors 9 with trisaccharide acceptor 16 and tetrasaccharide acceptor 27 followed by deprotection, respectively.

关 键 词：OLIGOSACCHARIDE trichloroacetimidate regio- and stereoselective synthesis 

分 类 号：O621[理学—有机化学]