内毒素致家兔急性肺损伤及前列腺素E_1治疗作用的研究  

THE ACUTE LUNG INJURY INDUCED BY E.COLI ENDOTOXIN AND THERAPEUTIC EFFECT OF PROSTAGLANDIN E_1 IN RABBITS

作　　者：汪建新[1] 黄念秋[1] 赵中苏[1] 施毅[1] 杨梅芳[1] 李维华[1] 

机构地区：[1]解放军总医院,100853

出　　处：《解放军医学杂志》1993年第4期257-260,共4页Medical Journal of Chinese People's Liberation Army

摘　　要：给家兔一次性静注内毒素(700μg/kg),复制急性肺损伤动物模型,观察到家兔呈休克状态,外周血白细胞和血小板减少,血浆TXB_2和6-keto-PGF_(1α)升高,血清ACE活性一过性升高后进行性下降,肺毛细血管通透性增加,肺内粒细胞扣押、微循环障碍、内皮和上皮细胞受损等肺组织损伤改变。采用PGE_1治疗内毒素所致的家兔急性肺损伤有一定疗效。A model of acute lung injury was reproduced by intravenous injection of endotoxin (700μg / kg) to rabbits. It had been found that the rabbits were in the state of shock, with leukopenia and thrombocytopenia, increased 6 -keto-PGF1α and TXB2, decreased serum ACE and increased permeability of the pulmonary capillaries. Granulocyte sequestration and disturbance in pulmonary microcirculation were found in lungs. A series of changes in epithelial and endothelial cells were also found in both lungs. It was obviously proved that PGE1 had some therapeutic effects in acute lung injury induced by E. coli endotoxin.

关 键 词：内毒素 肺损伤 前列腺素 血栓素 

分 类 号：R560.2[医药卫生—呼吸系统]