子宫内膜异位症伴疼痛患者血浆孤啡肽含量的变化  

STUDY ON THE RELATIONSHIP BETWEEN ORPHANIN FQ AND PAIN IN PATIENTS WITH ENDOMETRIOSIS

作　　者：胡电[1] 古航[2] 洪新如 金志军[1] 熊英[1] 侯庆香[1] 

机构地区：[1]第二军医大学长征医院妇产科,上海200003 [2]长海医院妇产科 [3]福州解放军总院妇产科

出　　处：《中国疼痛医学杂志》2004年第4期222-223,共2页Chinese Journal of Pain Medicine

摘　　要：目的 :观察子宫内膜异位症 (内异症 )伴疼痛者血浆孤啡肽水平的变化。方法 :采用放射免疫法测定 2 5例内异症无腹痛妇女 (对照组 )、31例内异症伴轻度腹痛妇女 (轻度组 )和 2 9例内异症伴重度腹痛妇女 (重度组 )血浆孤啡肽的含量。结果 :重度组血浆孤啡肽的含量为 39.82± 9.16ng .L 1,轻度组血浆孤啡肽的含量为 2 8.4 5± 7.38ng .L 1,对照组为 17.73± 4 .6 2ng .L 1。与对照组相比 ,前二组血浆孤啡肽含量显著上升 (P <0 .0 1及P <0 .0 5 ) ,其中重度组血浆孤啡肽的含量显著高于轻度疼痛组 (P <0 .0 5 )。结论 :血浆孤啡肽水平可能与子宫内膜异位症者疼痛的发生、发展密切相关。Objective:To evaluate the role of orphanin (OFQ) in the patients of endometriosis (EM) with pain. Methods:29 patients of EM with severe pain (severe group), 31 patients with slight pain (slight group) and 25 patients without pain(control group) were studied. The concentrations of plasma OFQ were measured by radioimmunoassay. Results:The levels of OFQ in severe group, slight group and control group were (39.82±9.16)ng.L -1 , (28.45±7.38)ng.L -1 and (17.73±4.62)ng.L -1 respectively. The level of plasma OFQ in pain group was significantly higher than that in the control group( P <0.01, P <0.05), the plasma OFQ in severe pain group was significantly higher than the slight pain group( P <0.05). Conclusions:Pain was associated with OFQ in patients of endometriosis with pain , the changes of OFQ levels in plasma may play an important role on pain modulation.

关 键 词：子宫内膜异位症 疼痛 血浆孤啡肽 放射免疫法 测定 

分 类 号：R711.71[医药卫生—妇产科学] R441.1[医药卫生—临床医学]