环磷腺苷葡胺对窒息新生儿缺氧性心肌损伤的保护作用  

The protective effect of meglumine adenosine cyclophosphate on myocardial hypoxia injury occurrence with asphyxia in neonates

作　　者：李元福[1] 张士发[2] 汤荣华[3] 

机构地区：[1]皖南医学院附属弋矶山医院 药剂科,安徽芜糊241001 [2]皖南医学院附属弋矶山医院 儿科,安徽芜湖241001 [3]皖南医学院附属弋矶山医院 检验科,安徽芜湖241001

出　　处：《皖南医学院学报》2004年第3期191-193,共3页Journal of Wannan Medical College

摘　　要：目的 探讨环磷腺苷葡胺对窒息新生儿缺氧性心肌损伤的保护作用。方法 58例缺氧性心肌损伤的窒息新生儿随机分为对照组和治疗组,分别检测血清肌酸激酶及同工酶的浓度。结果 静脉注射环磷腺苷葡胺治疗12天后,血清肌酸激酶(CK)及同工酶(CK-MB)较常规治疗组明显减低。结论 环磷腺苷葡胺对窒息新生儿缺氧性心肌损伤有明显的保护作用。Objective To explore the protective effect of meglumine adenosine cyclophosphate injecting on my-ocardial hypoxia injury after asphyxia. Methods 58 neonates with asphyxia myocardial damage were randomly divided into normal control and meglumine adenosine cyclophosphate administering group for detecting both ki-nase(CK) and kinase isoenzyme(CK-MB) level in serum. Results The serum level of CK and CK-MB in meglumine adenosine cyclophosphate administering group were markedly decreased in 12 days of intravenous injection of meglumine adenosine cyclophosphate. Conclusion Meglumine adenosine cyclophosphate has protective effect on myocardial hypoxia injury induced by asphyxia.

关 键 词：环磷腺苷葡胺 窒息 心肌损伤 新生儿 

分 类 号：R722.12[医药卫生—儿科]