Synthesis, Characterization of α-Oxopentanedioic Acid-Isonicotinoyl (Hydrazone) Rare Earth-Complexes and Relaxivity of Gd-complex  

作　　者：杨正银 杨汝栋 

机构地区：[1]State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China

出　　处：《Journal of Rare Earths》2004年第3期327-330,共4页稀土学报（英文版）

基　　金：ProjectsupportedbytheNationalNaturalScienceFoundationofChina ( 2 9975 0 12 )

摘　　要：Oxopentanedioic acid isonicotinoyl hydrazone (H_2L) and its five rare earth complexes were synthesized with a view to further investigating MRI activities of the polycarboxylic Schiff base complexes. The complexes were characterized on the basis of elemental analyses, IR, UV, (()~1H) NMR spectra and thermal analyses. The general formula of the complexes is [Ln(HL)(H_2O)_2]Cl_2·H_2O (where Ln(Ⅲ)=La, Pr, Nd, Eu and Gd). In addition, the relaxivity ( R _1) of the Gd-complex was determined by INVREC Au program.Oxopentanedioic acid isonicotinoyl hydrazone (H_2L) and its five rare earth complexes were synthesized with a view to further investigating MRI activities of the polycarboxylic Schiff base complexes. The complexes were characterized on the basis of elemental analyses, IR, UV, (()~1H) NMR spectra and thermal analyses. The general formula of the complexes is [Ln(HL)(H_2O)_2]Cl_2·H_2O (where Ln(Ⅲ)=La, Pr, Nd, Eu and Gd). In addition, the relaxivity ( R _1) of the Gd-complex was determined by INVREC Au program.

关 键 词：inorgonic chemistry MRI contrast agent RELAXIVITY rare earth complexes 

分 类 号：O641[理学—物理化学] O657.2[理学—化学]