心衰时淋巴细胞β受体密度的研究  

CHANGES IN β-ADRENOCEPTOR DENSITY OF LYMPHOCYTES IN HEART FAILURE

作　　者：何志原[1] 魏璇[1] 吕宝璋[2] 单京瑞 冷传福 

机构地区：[1]空军总医院,100036 [2]军事医学科学院 [3]空后门诊部

出　　处：《解放军医学杂志》1993年第4期254-256,共3页Medical Journal of Chinese People's Liberation Army

摘　　要：充血性心力衰竭患者在应用强心剂基础上,并用氨酰心安,于并用前及加用1周后,分别检测心脏指数、左心射血分数及血淋巴细胞β受体密度。并用前β受体密度明显低于正常值,并用后心功能改善的同时,血β受体密度升高(P<0.05)。同期慢性充血性心力衰竭(CHF)未用β阻滞剂组其β受体密度与治疗前比较亦有提高,但其P>0.05。表明β受体密度增高可能与β受体阻滞剂有关。心衰较重者其β受体密度极低,在并用氨酰心安过程中出现低血压、窦缓及房室传导阻滞,被迫停用β阻滞剂。本研究提示,β受体密度测定有助于临床判断是否对CHF患者加用β受体阻滞剂治疗,亦可以作为心功能恢复的参考指标。Atenolol was administered with cardiac glycosides in congestive heart failure patients. HI, LVEF and β-adrenoceptor density were measured before and one week after administration of the drugs. The density of β- adrenoceptor was significantly lower than the normal value before the administration. While it was increased significantly (P<0.05) concomitant with the improvement of cardiac function after the administration. Using diuretics instead of atenolol for one week, the density of β adrenoceptor was not significantly changed, although the cardiac function was improved. In the patients with severe heart failure and lower density of β adrenoceptor, administration of atenolol caused hypotension, severe sinus bradycardia and atrioventricular block, for which we have to stop the drug. The results suggest that administration of atenolol can induce β-adrenoceptor up-regula-tion. The measurement of the density of β -adrenoceptor is helpful for us to decide whether we should use ft adrenoceptor antagonists in heart failure and to judge the recovery of cardiac function.

关 键 词：心力衰竭 淋巴细胞 Β受体 

分 类 号：R541.603[医药卫生—心血管疾病]