抗抑郁药治疗胆囊切除术后慢性疼痛的临床研究  

A clinical study of neurostan on chronic pain after cholecystectomy

作　　者：陈玉龙[1] 尚杰[1] 王霞[1] 陈长阁[1] 刘华[1] 许春进[1] 

机构地区：[1]郑州大学第一附属医院消化内科,郑州450052

出　　处：《胃肠病学和肝病学杂志》2004年第4期409-410,共2页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的　评价路优泰治疗胆囊切除患者慢性疼痛的疗效。方法　将 64例慢性疼痛的胆囊切除患者随机分为抗抑郁剂路优泰组 3 2例和安慰剂组 3 2例 ,治疗 6周 ,应用慢性疼痛评价标准及汉密尔顿抑郁量表 (HAMD ;17项 )于治疗前及治疗第 1、2、4、6周末进行疗效评定。结果　路优泰组的 3 2例中有效率分别为 87.5 %和 84.4% ,而安慰剂组中的有效率分别为 2 8.1%和 3 4.4% ,两组比较差异有显著性 (P <0 .0 1)。Objective To evaluate the efficacy of neurostan in the treatment of patients with chronic pain after cholecystectomy.Methods Sixty four patients were randomly divided into two groups as neurostan group (32 cases) and placebo group (32 cases) and treated for 6 weeks.The criteria of the clinical therapeutic efficacy on chronic pain and Hamilton Depression Scale(HAMD;17 items) were used to assess the therapeutic effect before treatment and 1,2,4,6 weeks after treatment.Results The response rate on chronic pain and antidepression were 87.5%,84.4% in neurostan group and 28.1%,34.4% in placebo group respectively.There was a significant difference between the two groups( P <0.05).Conclusion Neurostan is one of the effective agents in the treatment of chronic pain.

关 键 词：抗抑郁药 治疗 胆囊切除术 慢性疼痛 临床研究 

分 类 号：R657.4[医药卫生—外科学]