33例银屑病病人6种抗磷脂抗体的检测  

Detection of six antiphospholipid antibodies in the sera from 33 patients with psoriasis

作　　者：郭哲[1] 赵玉铭[1] 王雅坤[1] 赖鑫[1] 陈洪铎[1] 

机构地区：[1]中国医科大学附属第一医院皮肤科

出　　处：《中国麻风皮肤病杂志》2004年第4期315-317,共3页China Journal of Leprosy and Skin Diseases

摘　　要：目的 :　探讨抗磷脂抗体 (APA)与银屑病的关系。方法 :　应用酶联免疫吸附试验 (ELISA)检测33例银屑病和 16例梅毒病人血中 6种APA。结果 :　①银屑病病人IgG型aCL、aPA、aPS、aPC和aPI的A值和aPI的阳性率较正常人显著升高 ;IgM型APA的A值较正常人显著降低 ,均阴性 ;②梅毒病人IgG型aCL、aPA、aPE和aPI的A值和aCL、aPA的阳性率较正常人显著升高 ;IgM型aCL、aPS、aPE和aPC的A值和aCL、aPS、aPE、aPC和aPI的阳性率较正常人显著升高。结论Objective:To determine the relationship between antiphospholipid antibodies and psoriasis. Methods:The distribution of six antiphospholipid antibodies were detected by enzyme linked immunosorbent assay in the sera from 33 patients with psoriasis and 16 patients with syphilis. Results:(1) Compared with normal controls, the A values of aCL, aPA, aPS, aPC and aPI and the positivity rates of aPI of IgG type in the sera from psoriasis patients were significantly higher. The A values of six antiphospholipid antibodies of IgM type in the sera from psoriasis patients were significantly lower. (2) The A values of aCL, aPA, aPE and aPI and the positivity rates of aCL and aPA of IgG type in the sera from syphilis patients were significantly higher. The A values of aCL, aPA, aPE and aPI and the positive rates of aCL、aPS、aPE, aPC and aPI of IgM type in the sera of syphilis were significantly higher. Conclusion: The mechanism of producing antiphospholipid antibodies between psoriasis and syphilis is different.

关 键 词：银屑病 抗磷脂抗体 检测 酶联免疫吸附试验 

分 类 号：R758.63[医药卫生—皮肤病学与性病学] R446.62[医药卫生—临床医学]