吸烟、饮酒与消化性溃疡关系的病例对照研究  

SMOKING DRINKING ALCOHOL AND PEPTIC ULCER

作　　者：韩成龙[1] 李彩宁[1] 孙安华[1] 李良寿[1] 

机构地区：[1]第四军医大学流行病学教研室

出　　处：《解放军预防医学杂志》1993年第3期190-194,共5页Journal of Preventive Medicine of Chinese People's Liberation Army

摘　　要：用流行病学病例对照研究方法,对120例经胃镜确诊的消化性溃疡患者和90例无上消化道疾病史的对照病人进行了对比分析.结果表明,吸烟者患胃溃疡的相对危险度(OR值)为不吸烟者的12.87倍(P<0.01);OR值与每日吸烟量及吸烟深度存在显著的剂量效应关系;戒烟1年以上者,OR值降低.吸烟与十二指肠溃疡有一定联系,但联系强度不如胃溃疡明显.饮酒也与胃溃疡和十二指肠溃疡的发病有关,特别是吸烟而且饮酒时,可显著增加消化性溃疡的发病危险性.By epidemiological case-control study method,we investigated smoking and drinking alcohol habits among one hundred and twenty patients with peptic ulcer (PU),diagnosed with gastroscopy,and ninety non-ulcer control patients.It was found that smoking was statistically associated with gastric ulcer(GU),with odds ratio (OR)being 12.87(p<0.001).There was an increase of risk for GU with the increase of cigarette smoke consumed daily and with depth of inhaling smoke.Similar association was also found between smoking and duodenal ulcer (DU),which,however,was not so strong as that found between smoking and GU. Drinking alcohol was also one of the risk factors for both GU and DU,with OR being 2.96,2.65,respectively (p<0.05).Statistical significant dose-response relationship between alcohol amount drunk per time and risk for both GU and DU was also found.Smoking and drinking alcohol exhibited synergic effect on the development of PU.

关 键 词：消化性溃疡 吸烟 饮酒 病例对照 

分 类 号：R825.7[医药卫生—临床医学]