氯沙坦配合加味六味地黄汤对老年糖尿病肾病早期尿微量白蛋白排泄率的影响  

The effect of UAE in early stage of senile diabetic nephrotic syndrome treated with Losartan and compound Liu Wei Oi Huang Tang

作　　者：魏连波[1] 陈旭红 马志刚[1] 叶任高[3] 吕瑞和[1] 栾图 方敬爱[4] 栾明一[1] 李玉芳[1] 

机构地区：[1]广东省广州市第一军医大学南方医院中医内科,广州510515 [2]广东省广州市残联培训中心,广州510000 [3]中山医科大学附属第一医院肾脏病研究所,广州510080 [4]山西医科大学第一附属医院肾内科,太原030001

出　　处：《中国中西医结合肾病杂志》2000年第2期85-87,共3页Chinese Journal of Integrated Traditional and Western Nephrology

摘　　要：目的:探讨氯沙坦配合加味六味地黄汤对老年糖尿病肾病(DN)早期尿微量白蛋白排泄率(UAE)的影响。方法:62例随机分为治疗组和对照组,治疗组31例用氯沙坦、加味六味地黄汤;对照组31例用哌唑嗪。两组均用糖适平、维生素E、潘生丁。观察24hUAE、肾小球滤过率((GFR)、平均动脉压(MAP)的变化。结果:治疗组极显著地减少老年DN的UAE,并明显优于对照组(P=0.000)。治疗组使肾小球高滤过恢复正常,并优于对照组(P=0.000)。两组治疗后MAP均降至正常。结论:氯沙坦配合加味六味地黄汤显著减少老年DN的UAE。Objective: To discuss the effect of UAE in senile diabetic nephrotic syndrome treated with Losartan and Compound Liu Wei Di Huang Tang . Methods: 62 cases of patients were divided into treatment group. And control group. Losartan and Liu Wei Di Huang Tang were given in treatment group. And Prazosin was given in control group . And Glurenorm Vitamin E and Persantin were given in both group . To observe the change of 24h UAE , GRF and MAP . Results: In treatment group , the UAE has a sharp decrease , and the high GFR was regained , both of them was more significant compared with control group, and the MAP was regained in both group . Conclusion: Treatment with Losartan and compound Liu Wei Di Huang Tang , the UAE can be decreased obviously in senile DN patients.

关 键 词：氯沙坦 配合 六味地黄汤 糖尿病肾病 尿微量白蛋白 排泄率 老年人 

分 类 号：R587.2[医药卫生—内分泌]