反相离子对色谱法测定羧甲司坦片和口服溶液中羧甲司坦的含量  

DETERMINATION OF CARBOCISTEINE IN CARBOCISTEINE TABLETS AND ORAL SOLUTION BY REVERSED ION-PAIR PHASE HPLC

作　　者：赵雪梅[1] 杨颖[1] 黎志芳[1] 

机构地区：[1]广州市药品检验所,510160

出　　处：《中国药品标准》2000年第2期37-39,共3页Drug Standards of China

摘　　要：目的:建立反相离子对色谱法,测定羧甲司坦片和口服溶液中羧甲司坦的含量。方法:采C_(18)柱,以含0.05％庚烷磺酸钠的0.05mol/L磷酸二氢钾溶液(用磷酸调pH2.5)为流动相。检测波长215nm。结果:该方法羧甲司坦片剂和口服溶液的回收率分别为100.3％,RSD=0.54％(n=5),100.5％,RSD=0.70％(n=5)。结论:该法准确,可靠,专一性强,能满足制剂质量标准的要求。Objective. A Reversed ion-pair phase HPLC method has been studied to determine the contents of carbocisteine in Carbocisteine Tablets and Oral solution. Method: The chromatographic condion are Listed below: C_(18) column, detection wavelength 215 nm, and a mobile phase 0.05mol/L K_2HPO_4(containing 0.05％Sodium heptanesulfonate and pH ajuested to 2.5 with phosphovic scid), Results: The recoveries for Carbocisteine Tablets and Oral solution in the method are 100.3％ (RSD0.54％, n=5). and 100.5％(RSD=0.70％, n=5), respectively. Conclusion: The method is simple, rapid and reliable

关 键 词：反相离子对色谱法 测定 羧甲司坦片 口服溶液 羧甲司坦 含量 

分 类 号：R927.2[医药卫生—药学]