葛根素对高血压病患者血浆ET及TXB_2、6-K-PGF_(1α)含量的影响  

Puerarine effect on the quantity of plasma TXB_2,6-k-PGF_(1α) in patients with hypertension

作　　者：罗伟[1] 李保东[1] 杨瑞华 冯小平 

机构地区：[1]徐州市第四人民医院,江苏徐州221009 [2]徐州市心血管病研究所,江苏徐州221009

出　　处：《中国中医基础医学杂志》2000年第1期45-47,共3页JOURNAL OF BASIC CHINESE MEDICINE

摘　　要：目的:观察高血压病患者血浆内皮素(ET)、血栓素B2(TXB2)、6-酮-前列腺素F1α(6K-PGF1α)含量的变化及葛根素对其影响。方法:60例高血压病患者随机分为基础治疗组(对照组)和基础治疗加葛根素治疗组(葛根素组)。以放射免疫法检测治疗前后血浆ET、TXB2、6-K-PGF1α含量的变化。结果:高血压病患者血浆ET、TXB2的含量显著增高(P<0.05～0.01),6-K-PGF1α含量明显降低(P<0.05)。应用葛根素治疗后ET含量很快下降(P<0.01),TXB2含量降低(P<0.05),6-K-PGF1α含量显著提高(P<0.01)。结论:葛根素能有效降低高血压病患者内皮素的过量释放,纠正循环中TXA2-PGI2平衡失调。提示葛根素对高血压病有积极的治疗价值。Objective:To observate the changes of plasma ET,TXB 2 and 6 k PGF 1α ,and investigate Puerarine how to effect on these changes.Method:60 cases of patients with hypertension were randomly divided into two group:puerarine theraputic group;contral group.The level of plasma ET,TXB 2 and 6 k PGF 1α were measured by EIA.Results:The level of plasma ET,TXB 2 and 6 k PGF 1α increased markedly,but 6 k PGF 1α decreased in patients with hypertension.After using puerarine,the level of plasma ET,TXB 2 down,but 6 k PGF 1α up.Conclusion:Puerarine could inhibit the lease of a great deal of ET and readjust TXB 2 and 6 k PGF 1α ratio.These results induced that puerarine has theraputic value for hypertension.

关 键 词：高血压病 葛根素 TXB2 患者 含量 血浆ET PGI2 结论 变化 纠正 

分 类 号：R544.1[医药卫生—心血管疾病] R743[医药卫生—内科学]