渴痹康对糖尿病大鼠坐骨神经中cAMP、cGMP含量的影响  

Effect of Kebikang on the contents of CAMP and cGMP of the sciatic Nerve in the Diabetic Rats

作　　者：王昕[1] 王宏才[1] 田德全[1] 陈丁生[1] 朱丽霞[1] 

机构地区：[1]中国中医研究院针灸研究所,北京100700

出　　处：《中国中医基础医学杂志》2000年第2期20-22,共3页JOURNAL OF BASIC CHINESE MEDICINE

摘　　要：目的:观察中药“渴痹康”对糖尿病大鼠坐骨神经中cAMP、cGMP含量的影响。方法:用链脲佐菌素(STZ)诱发大鼠实验性糖尿病神经病变,用含渴痹康药液的饵料喂饲大鼠4个月后,取出坐骨神经,用放射免疫的方法测定cAMP、cGMP的含量。结果:糖尿病(DM)大鼠坐骨神经中cAMP、cGMP含量与正常组(ND)大鼠相比明显下降(P<001)。渴痹康治疗组(KBK)与DM组比较有明显差异(P<001)。ND组与KBK组比较变化不明显。结论:渴痹康可防止糖尿病大鼠坐骨神经中cAMP、cGMP含量的下降。Objective: Effect of chinese herb(KBK)was observed by concerntration of cAMP and cGMP of the sciatic nerve in the diabetic rats.Method: Intraperitoneal administration of striptotoxin(STZ) produced diabetes in the Wister rats.One week after STZ injection the animals were considered to be the diabetes if their blood glucose were higher than 16.7 mM.Then,the diabetic rats were randomly divided into two groups,diabetic control group(DM,n=9)and Kebikang treated group(KBK,n=11).KBK group were treated with Kebikang and DM group remaned no treatment.Four month after treatment the animals were sacrificed and their sciatic nerves were taken out for cAMP and cGMP detection.Result:The concentration of cAMP and cGMP in the sciatic nerve of DM rats was significantly decreased than that in ND and KBK group( P <0.01,respectively).There was no significant difference between ND and KBK groups.Conclusion The KBK may prevent the decrease of the contents of cAMP and cGMP of the diabetic sciatic nerve.

关 键 词：坐骨神经 糖尿病大鼠 含量 AMP GMP 实验性糖尿病 取出 变化 放射免疫 

分 类 号：R587[医药卫生—内分泌] R651[医药卫生—内科学]