补阳还五汤注射液对大鼠静脉血栓形成前后静脉血中血小板活化因子含量的影响  

Laboratory Study on Buyang Huanwu Injection's Effects on Content of Rats' PAF in Venous Blood Prior and Subsequent to Experimental Venous Thrombosis

作　　者：张继平[1] 李长龄[2] 郭欣欣[2] 王桂玲[2] 

机构地区：[1]广东省佛山市中医院,广东佛山528000 [2]北京医科大学药学院,北京100083

出　　处：《中国中医基础医学杂志》2000年第12期18-20,共3页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家中医药管理局科研基金资助项目! (课题合同号 :93 C0 2 9);广东省中医药管理局科研基金资助项目! (课题编号 :93 0 3 9)

摘　　要：目的 :探讨补阳还五汤注射液静脉注射对实验性静脉血栓形成前后静脉血中血小板活化因子(PAF)含量的影响。方法 :应用大鼠实验性静脉血栓模型及 PAF含量的生物测定法。结果 :补阳还五汤注射液可明显降低静脉血栓干重和血栓 -体重指数 (P<0 .0 5) ;但对大鼠静脉血栓形成前后静脉血中 PAF含量和血栓形成百分率无明显影响 (P<0 .0 5)。结论 :补阳还五汤注射液对静脉血栓的发展有一定的抑制作用 ,但对静脉血栓的发生和Objective:To observe the effects of Buyang Huanwu Injection on the platelet activating factor(PAF) of rats with experimental venous thrombus.Methods:Rat models with venous experimental thrombus were made and the content of PAF was measured by bioassay.Results:The dry weight of venous thrombus and the thrombus\|weight index were markedly reduced ( P <0 05).The content of rats' PAF in venous blood prior and subsequent to thrombosis and the percentage of venous thrombosis were not affected.Conclusion:All the results above suggest that Buyang Huanwu Injection has particularly inhibited to the growth of venous thrombus,but has no effect on of thrombosis and content of PAF.

关 键 词：注射液 静脉血栓形成 补阳还五汤 PAF 含量 大鼠 血小板活化因子 结论 百分率 目的 

分 类 号：R543[医药卫生—心血管疾病] R743[医药卫生—内科学]