小四五颗粒对糖尿病肾病(DN)大鼠一氧化氮(NO)血脂变化的实验研究  

Experimental Study of the Nitric Oxide and Serum Lipid of XSW Granule on the Diabetic Nephropathy Rats

作　　者：董晓蕾[1] 雷作熹[1] 徐俊[1] 罗仁[1] 

机构地区：[1]第一军医大学中医系,广州510515

出　　处：《中国血液流变学杂志》2004年第3期299-300,304,共3页Chinese Journal of Hemorheology

基　　金：广东省自然科学基金 (编号 0 13 0 40 );广东省中医药管理局科研基金资助课题 (编号 10 10 0 4)

摘　　要：目的　研究小四五颗粒 (XSW)对DN大鼠的NO、血脂的变化 ,探讨其治疗DN作用机制。方法用STZ腹腔注射法诱导大鼠DN ,治疗 12周。观察大鼠血糖、NO、血脂 (胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白 )的变化。结果　无糖无改变 ,NO含量增高 ,胆固醇、甘油三酯降低。结论　XSW对NO、血脂具有调节作用 ,改善血流动力学是XSW治疗DN的作用机制。Objective To observe nitric oxide and serum lipid effect of Xiao-Si-Wu Granule (XSW) on renal function of streptozotocin (STZ)-induced diabetic nephropathy rats, trying to find the correlation therapeutic mechanism of the XSW to the diabetic nephropathy. Methods Diabetic nephropathy rats induced by intraperitoneal injection of STZ were treated with three dosages of XSW for 12 weeks, at the same time a group of DC rats were in control. During and after the treatment, rats in the experiment group as well as control group were observed for their blood glucose levels, nitric oxide, serum lipid. Results After XSW treatment, it seemed that XSW had no effect on the blood glucose levels, while they could increase the nitric oxide, and significantly decrease serum lipid.Conclusion Present study suggests that XSW could increase the nitric oxide and decrease serum lipid. It is perhaps the regulation of lipid is responsible for the correlation therapeutic mechanism of XSW.

关 键 词：小四五颗粒 糖尿病肾病 DN 大鼠 一氧化氮 NO 血脂变化 实验 

分 类 号：R259.872[医药卫生—中西医结合] R277.52[医药卫生—中医内科学]