Enantioseparation of Novel Chiral Tetrahedral Clusters on an Amylose Tris-(3,5-dimethylphenylcarbamate) Chiral Stationary Phase by Normal Phase HPLC  

作　　者：李文智 王霞 张伟强 陈立仁 李永民 马春林 殷元骐 

机构地区：[1]Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences [2]Department of Chemistry, Liaocheng University, Liaocheng, Shandong 252059, China

出　　处：《Chinese Journal of Chemistry》2004年第10期1070-1074,共5页中国化学（英文版）

基　　金：Project supported by Chinese Academy of Science (No. KY95-S1-205).

摘　　要：Amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) coated on a kind of small particle silica gel was pre-pared. On this ADMPC chiral stationary phase (CSP), the direct enantiomeric separation of six novel chiral transi-tion metal tetrahedral clusters has firstly been achieved using n-hexane as the mobile phase containing various al-cohols as modifiers. The effect of mobile phase modifiers and the structural variation of the solutes on their reten-tion factors (k) and resolutions (Rs) were investigated. The result suggests that not only the structure and concentra-tion of alcohol in mobile phase, but also the structural differences in racemates can have a pronounced effect on enantiomeric separation. ADMPC-CSP is a suitable CSP for the optical resolution of chiral tetrahedral cluster by HPLC.Amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) coated on a kind of small particle silica gel was pre-pared. On this ADMPC chiral stationary phase (CSP), the direct enantiomeric separation of six novel chiral transi-tion metal tetrahedral clusters has firstly been achieved using n-hexane as the mobile phase containing various al-cohols as modifiers. The effect of mobile phase modifiers and the structural variation of the solutes on their reten-tion factors (k) and resolutions (Rs) were investigated. The result suggests that not only the structure and concentra-tion of alcohol in mobile phase, but also the structural differences in racemates can have a pronounced effect on enantiomeric separation. ADMPC-CSP is a suitable CSP for the optical resolution of chiral tetrahedral cluster by HPLC.

关 键 词：enantiomeric separation HPLC chiral stationary phase amylose tris(3 5-dimethylphenylcarbamate) chiral tetrahedral cluster 

分 类 号：O621[理学—有机化学] O657.7[理学—化学]