Synthesis and Photocytotoxicity of Mono-functionalised Porphyrin with Valine Moiety  

作　　者：WeiMinSHI JianWU YiFengWU KaiXianQIAN 

机构地区：[1]DepartmentofChemistry,ZhejiangUniversity,YuquanCampus,Hangzhou310027 [2]DepartmentofBiology,ZhejiangUniversity,YuquanCampus,Hangzhou310027

出　　处：《Chinese Chemical Letters》2004年第12期1427-1429,共3页中国化学快报（英文版）

摘　　要：A mono-funtionalised tetraphenylporphyrin (TPP) bearing valine moiety at the phenylring was synthesized for photocytotoxicity examination in four steps, starting from regiospecificmono-nitration of TPP at the phenyl ring. The in vitro photocytotoxicitic effect against SPC-Aladenocarcinona cell line was tested.A mono-funtionalised tetraphenylporphyrin (TPP) bearing valine moiety at the phenylring was synthesized for photocytotoxicity examination in four steps, starting from regiospecificmono-nitration of TPP at the phenyl ring. The in vitro photocytotoxicitic effect against SPC-Aladenocarcinona cell line was tested.

关 键 词：Mono-functionalised PORPHYRIN tetraphenylporphyrin photocytotoxicity. 

分 类 号：O626[理学—有机化学]