健胃愈疡颗粒对胃溃疡复发大鼠胃组织VEGF mRNA表达的影响  

Effect of jianweiyuyang granules on expression of VEGF mRNA in gasrtic tissue of rats with gastric ulcer recurrence?

作　　者：戴幸平[1] 李家邦[1] 周兵[1] 蒋荣鑫[1] 吴贤玲[1] 周勇杰[1] 

机构地区：[1]中南大学湘雅医院中西医结合研究所,湖南长沙410008

出　　处：《中国医学工程》2004年第5期4-7,共4页China Medical Engineering

基　　金：湖南省卫生厅中医药科研基金课题(202053)

摘　　要：目的以IL-1β所致胃溃疡复发大鼠为模型,探讨健胃愈疡颗粒抗复发机制。方法以Okeba改良法复制大鼠实验性胃溃疡,腹腔注射IL-1β制作复发模型。采用RT-PCR法观察该药对胃溃疡组织血管内皮生长因子(Vascularendothelialgrowthfactor,VEGFmRNA)表达的影响。结果健胃愈疡组VEGFmR-NA的表达较模型组及对照组显著增高。结论健胃愈疡颗粒可增高VEGFmRNA的上增性表达,这可能是其促进溃疡愈合,减少溃疡复发的机制之一。Objective: To study the effect of Jianweiyuyang (JWYY) Granules on rats with gastric ulcer recurrence and investigate the mechanism of the JWYY to prevent the recurrence of gastric ulcer. Methods: The gastric ulcer was induced in rat by Okeba′s method with some modification and the recurrence model caused by IL-1β. The expression of Vascular endothelial growth factor mRNA (VEGF mRNA) was examined by reverse transcription polymerase chain reaction (RT-PCR) in gastric ulcer. Results: VEGF mRNA expression in gastric tissues during the healing process in JWYY group significantly increased compared with the normal, model and Ranitidine treatment groups. Conclusion: It is indicated that Jianweiyuyang Granules can enhance the expression of VEGF mRNA and that may be the mechanism of JWYY treating and preventing recurrence of gastric ulcer.

关 键 词：健胃愈疡颗粒 胃溃疡 复发 大鼠 胃组织 VEGFMRNA 基因表达 中药制剂 

分 类 号：R259.731[医药卫生—中西医结合]