大剂量干扰素治疗重症肝炎疗效观察  

Treatment of Severe Viral Hepatitis with Large Doses of Interferon

作　　者：朱坚胜[1] 王家驹[1] 

机构地区：[1]浙江省台州医院,临海317000

出　　处：《科技通报》1993年第4期268-270,共3页Bulletin of Science and Technology

摘　　要：在综合治疗基础上加用大剂量人血白细胞干扰素治疗14例慢性重症肝炎,1例亚急性重症肝炎.前7d采用1×10~6UImq8h,以后1×10~6UImqd,总量大于30×10~6U,结果15例中存活10例,占66.7％,存活率比以往综合治疗明显提高.14例乙肝标志物检查结果:HBeAg或抗-HBcIgM有一项阳性者占100％,提示病毒处于复制状态,治疗后HBeAg阴转率为85.7％,抗-HBcIgM阴转率为100％,HBsAg阴转率为12.5％,显示抗病毒效果显著。Based on comprehensive treatment, 14 patients with chronic severe viral hepatitis and 1 patient with sub- acute severe viral hepatitis were treated with large-dose of human leukocytic interferon. The dosage and regi- men were as follows: 1×10~6 ui. m. q8h on day to seven, then 1×10~6 ui. m. q. d. the total dose was over 30× 10~6u. It was found that 10 cases survived and the survival rate was 66.7％, Which was much higher than that of previous comprehensive treatment. Before treatment, the rate of positive HBeAg or anti-HBcIgM were 100％ in HBVM of 14 cases, which might be represented the replicating state of the virus. After treatment, the seroconversion rates of negative HBeAg. anti-HBcIgM and HBsAg were 85.7％, 100％ and 12.5％ re- spectively. It was indicated that large-dose interferon treatment was highly effective.

关 键 词：干扰素 肝炎 重症肝炎 免疫疗法 

分 类 号：R512.6[医药卫生—内科学]