三重-比导数分光光度法及其应用研究  

Triple ratio derivative spectrophotometry and its application

作　　者：徐嘉凉[1] 安东[1] 冯征宇[1] 肖伟[1] 汤晓东[1] 

机构地区：[1]华东理工大学金山校区,上海201512

出　　处：《分析试验室》2004年第10期36-39,共4页Chinese Journal of Analysis Laboratory

摘　　要：提出了可以应用于三元混合物同时测定的三重 比导数分光光度法,阐述了三重 比导数分光光度法的基本原理,研究了三重 比导数分光光度法在三元复方制剂增效联磺片中磺胺甲口恶唑(SMZ)、磺胺嘧啶(SD)、甲氧苄啶(TMP)的同时测定。试验结果表明,增效联磺片中SMZ、SD、TMP的回收率分别为102 1%(RSD=2.7%,n=20)、100.5%(RSD=1.8%,n=20)、101.2%(RSD=4 3%,n=20)。The triple ratio derivative spectrophotometry was used for simultaneous determination of a ternary mixture by the method was discussed. The simultaneous determination of three components in pharmaceutical containing sulfamethoxazole, sulfadiazine and trimethoprim by the method was studied and the results were satisfactory. The average recoveries of sulfamethoxazole, sulfadiazine and trimethoprim were 102.1% (RSD=2.7%, n=20), 100.5%(RSD=1.8%, n=20), and 101.2%(RSD=4.3%, n=20), respectively.

关 键 词：三重-比导数分光光度法 三元混合物 同时测定 增效联磺片 磺胺甲嚷唑 磺胺嘧啶 甲氧苄啶 含量测定 

分 类 号：R978[医药卫生—药品] R927.2[医药卫生—药学]