子宫内膜异位症患者血清EMAb、ASAb检测的临床意义  

Study of EMAb and ASAb in the serum of endometriosis

作　　者：刘瑾[1] 张磊[1] 赵晓岚[1] 晋芳[1] 蔡小宁[1] 刘琦[1] 

机构地区：[1]西安交通大学第二医院妇产科,西安710004

出　　处：《陕西医学杂志》2004年第11期985-986,1002,共3页Shaanxi Medical Journal

摘　　要：目的 :探讨子宫内膜异位症患者血清中抗子宫内膜抗体 ( EMAb)、抗精子抗体( ASAb)的表达情况 ,并研究子宫内膜异位症合并不孕与 EMAb、ASAb的关系。方法 :采用酶联免疫吸附试验 ( EL ISA)法检测 5 4例子宫内膜异位症患者 ( EMT组 )血清中 EMAb、ASAb阳性情况 ,并与 5 4例健康妇女 (对照组 )进行比较。结果 :EMT组 EMAb的阳性率为68.5 2 % ( 37/5 4 ) ,显著高于对照组 3.70 % ( 2 /5 4 ) ( P<0 .0 1 ) ;EMT组 ASAb阳性率 1 4.81 % ( 8/5 4 )高于对照组 1 .85 % ( 1 /5 4 ) ( P<0 .0 5 ) ;EMT组不孕症患者 EMAb阳性率 93.75 % ( 1 5 /1 6)与无不孕组 5 7.89% ( 2 2 /38)比较有显著性差异 ( P<0 .0 1 ) ;ASAb的阳性率为37.5 0 % ( 6/1 6)显著高于对照组 5 .2 6% ( 2 /38) ( P<0 .0 1 )。结论 :子宫内膜异位症与EMAb、ASAb密切相关 ,EMAb、ASAb是导致子宫内膜异位症不孕的原因之一。Objective: To study the expression of endometrial antibody(EMAb) and anti-sperm antibody(ASAb) in the serum of endometriosis. Methods: Enzyme linked immonosorbent assay (ELISA) was applied to detect EMAb and ASAb in 54 serum samples of endometriosis(EMT group) and 54 healthy women(control group) . Results: The positive rate of EMAb 68.52%(37/54) in the EMT group was significantly higher than control group3.70%(2/54)(P<0.01) and that of ASAb 14.81%(8/54)was also higher than control group 1.85%(1/54)(P<0.05); The positive rate of EMAb93.75%(15/16)was significantly higher than fertility group 57.89%(22/38) (P<0.01)and ASAb 37.50%(6/16)was higher than non-infertility of EMT group 5.26%(2/38)(P<0.01). Conclusion: EMAb and ASAb were closely related to endometriosis; EMAb and ASAb were part of reasons for infertility of endometriosis.

关 键 词：子宫内膜异位症 血清 EMAB ASAb 检测 抗子宫内膜抗体 抗精子抗体 

分 类 号：R711.71[医药卫生—妇产科学]