康肤霜治疗Ⅱ度烧伤创面临床观察  

A clinical observation of Kangfushuang to treat the partial and full thickness burn wounds

作　　者：童亚林[1] 朱金红[1] 缪洪城[1] 潘葵[1] 杨福旺[1] 孔质彬[1] 龚震宇[1] 

机构地区：[1]桂林解放军第一八一医院烧伤整形科,541002

出　　处：《中国康复医学杂志》2004年第9期681-683,共3页Chinese Journal of Rehabilitation Medicine

摘　　要：目的:观察康肤霜(Kangfushuang,KFS)治疗Ⅱ度烧伤创面疗效及安全性。方法:将病人分成KFS和重组人表皮细胞生长因子(rhEGF)、紫花烧伤膏(ZHSSG)、0.5%碘伏(0.5%ComplexIodine,COI)治疗组。比较四种药物体外抑菌环、创面愈合时间,观察康肤霜可能出现的不良反应(肝肾功能、白细胞记数、皮肤过敏反应及创面疼痛)。结果:KFS与COI相比各细菌抑菌环均无差异(P>0.05);KFS与ZHSSG、rhEGF相比,对金黄色葡萄球菌、大肠杆菌抑菌环均有差异(P<0.01);而四种药物对绿脓杆菌的抑菌环均无差异(P>0.05)。浅Ⅱ度创面愈合时间:KFS与rhEGF、ZHSSG差异无显著性(P>0.05),而短于COI(P<0.01);深Ⅱ度创面愈合时间:KFS与rhEGF差异无显著性(P>0.05),但短于ZHSSG(P<0.05)及COI(P<0.01)。治疗中未发现KFS不良反应。结论:KFS明显加速创面愈合且无不良反应。Objective:To investigate the effect and the safety of Kangfushuang(KFS) in treating the partial and full thickness burn wound.Method:The patients were divided into KFS treatment group and 3 control groups (rhEGF,ZHSSG,COI). The antibiotic cyclome diameter of in vitro of the 4 kinds of drugs were tested.The wounds healing time and the adverse reaction of KFS(such as liver function,kidney function,leukocytes sum,wound pain)were observed.Result:KFS and COI were similar in the antibiotic cyclome diameter of 3 kinds of bacteria(P>0.05).KFS was the largest one comparing to rhEGF and ZHSSG in the antibiotic cyclome diameter of Staphylococcus-aureus and bacterium-coli(P<0.01). But the 4 druges do not differ statistically(P>05) in the antibiotic cyclome diameter of bacterium-aerogenes. The partial thickness burn wounds healing time of KFS was as long as rhEGF and ZHSSG(P>0.05) and shorter than COI(P<0.01).The full thickness burn wounds healing time of KFS was so long as rhEGF(P>0.05), but KFS was shorter than ZHSSG(P<0.05) and COI(P<0.01).The adverse reactions of KFS were not discovered.Conclusion:KFS may evidently accelerate partial and full thickness burn wounds healing,and its adverse reaction weren′t found.

关 键 词：康肤霜 治疗 Ⅱ度烧伤 安全性 重组人表皮细胞生长因子 紫花烧伤膏 

分 类 号：R644[医药卫生—外科学]