传统宫颈细胞学与液基薄层细胞/TBS检测方法用于宫颈病变早期筛查的比较研究  

Comparison of Papanicolaou and TCT on Early Screening of Cervical Diseases

作　　者：冯睿[1] 王倩[1] 邱新娇[1] 周欣[1] 李红英[1] 谢卫芳[1] 高玮[1] 黄汉星[1] 

机构地区：[1]深圳市南山区计划生育服务中心,518051

出　　处：《中国计划生育学杂志》2004年第11期679-680,共2页Chinese Journal of Family Planning

摘　　要：目的 :比较与评价传统宫颈细胞学 /巴氏分级与液基薄层细胞 /TBS检测系统对子宫颈癌及癌前病变的筛查效果。方法 :于 2 0 0 4年 2～ 9月对 2 184例健康育龄妇女随机采用传统宫颈细胞涂片 /巴氏分级法和液基薄层细胞涂片 /TBS分级法检测 ,进行宫颈病变的早期筛查 ,并对细胞学阳性病例进行人乳头瘤病毒 (HPV)检测和阴道镜下活检。结果 :传统宫颈细胞学检查对宫颈上皮内瘤样变 (CIN)及人乳头瘤病毒 (HPV)感染的检出率 (2 0 0 0 %、10 0 0 % )明显低于液基薄层细胞 /TBS检测结果 (4 2 2 2 %、4 0 0 0 % ) ,二者比较差异有显著性 (P <0 0 5 )。结论 :液基薄层细胞/TBS检测系统对CIN、HPV的检出率均高于传统宫颈细胞学检查 ,是早期筛查宫颈癌及癌前病变敏感而准确的方法 ,值得推广。Objective: To compare with two methods of Papanicolaou and TCT on early screening of cervical cancer and precancerous pathological changes. Methods: 2184 healthy women from January to September 2004 received an early cervical screening by Papanicolaou or TCT. Among them, those with positive disease received the colpomicroscopy and HPV examination. The cytological results were compared with pathologic examination. Results: The sensitivity of Papanicolaou for cervical intraepithelial neoplasia (CIN) and human papilloma virus (HPV) infection was 20.00% and 10.00%, respectively, and they were lower than that in TCT (42.22% and 40.00%). There was significant difference between two methods (P<0.05). Conclusion: TCT is a safe and accurate way of early screening of cervical cancer and precancerous pathological changes, superior to Papanicolaou.

关 键 词：宫颈细胞学 液基薄层细胞 TBS检测 宫颈病变 早期筛查 

分 类 号：R711.74[医药卫生—妇产科学]