血红素氧合酶在慢性阻塞性肺疾病患者中表达的初步探讨  

The bioloration of heme oxygenase expressions in patients with chronic obstructicve pulmonary disease

作　　者：裘晓华 陈志萍[2] 颜松旭[2] 

机构地区：[1]浙江省舟山市海洋学院医学院,316000 [2]浙江省舟山市人民医院,316004

出　　处：《浙江临床医学》2004年第11期932-933,共2页Zhejiang Clinical Medical Journal

摘　　要：目的 观察血红素氧合酶 (HO)在慢性阻塞性肺疾病患者中表达及其变化的临床意义。方法 应用分光光度计法测定40例COPD患者动脉血一氧化碳血红蛋白 (HbCO)含量和血红素氧合酶 (HO -1)活性 ,并与40例单纯肺癌患者和40例正常健康者对照 ,且3组均进行血气分析和肺功能测定对照。结果 COPD组HbCO和HO -1明显高于单纯肺癌组和正常健康组 ,差异有显著意义 (p<0.01)。单纯肺癌组和正常健康组比较差异无显著性。结论 COPD患者HOObjective To explore the heme oxygenase(HO)expressions in patients with chronic obstructive pulmonary disease(COPD). Methods 120patients were divided into3groups:COPD(group1,n=40),lung cancer group(group2,n=40),healthy controls(group3,n=40).Blood gas analysis and pulmonary function were assayed in all groups.The levels of carbon monoxide hemoglobin(HbCO)and HO-1activity in arterial blood of all patients were tested with ultraviolet spectrophotometry. Results The levels of HbCO and HO-1expression were significantly higher in the patients of group1than those of group2and group3(p<0.01).But they had not significant difference between group2and group3(p>0.05). Conclusion the overexpression of HO may be a compensatory regulation.Endogenous HO-CO system might involved in the regulation of COPD.

关 键 词：血红素氧合酶 慢性阻塞性肺疾病 表达 一氧化碳血红蛋白 

分 类 号：R563.9[医药卫生—呼吸系统]