凯时注射液治疗慢性肝病黄疸  

EFFECTS OF KAISHI INJECTION ON JAUNDICE IN PATIENTS WITH CHRONIC HEPATOPATHY

作　　者：乐桥良[1] 张志坚[1] 林克荣[1] 王雯[1] 朱金照[1] 张晓兰[1] 

机构地区：[1]福州总医院消化内科

出　　处：《福州总医院学报》2004年第2期76-78,共3页Journal of Fuzhou General Hospital

摘　　要：目的:评价凯时注射液(kaishiinjection)洽疗慢性肝病黄疸的疗效。方法:将58例慢性肝病黄疸患者随机分为凯时注射液组和对照组;凯时注射液组在对照组基础(葡萄糖、肌苷、维生素C及肝泰乐等)上加用凯时注射液10μg·d-1,静脉注射,疗程4周;测定治疗前后总胆红素(TB)、直接胆红素(DB)、丙氨酸转氨酶(ALT)、门冬氨酸转氨酶(AST)、碱性磷酸酶(AKP)、白蛋白(ALB)及球蛋白(GLB)等含最的变化;并观察症状和体征变化及不良反应。结果:在治疗4周后,凯时注射液组和对照组显效率分别为30.00%(9/30)和14.29%(4/28),有效率分别为53.33%(16/30)和42.86%(12/28),无效率分别为16.67%(5/30)和42.86%(12/28),凯时注射液组总有效率83.33%(25/30)明显优于对照组57.14%(16/28)(P<0.05);凯时注射液能明显降低慢性肝病黄疸患者的TB、DB、AKP、ALT和AST(P<0.05),对ALB和GLB则无明显影响(P<0.05);两组均无明显副作用。结论:凯时注射液能有效治疗慢性肝病的黄疸,且副作用少。Objective: To evaluate the effects of kaishi injection on jaundice in patients with chronic hepatopathy. Method: 58 chronic hepatopathy patients with jaundice were randomly divided into kaishi injection group and control group. In kaishi injection group kaishi injection was given intravenous infusion at the dosage of 10μg·d-1 for four weeks with the treatment of control group (glucose, hypoxanthosine, vitamin C and febuprol). Total bilirubin (TB), direct bilirubin (DB), alkaline phosphatase (AKP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum albumin (ALB) and serum globulin (GLB) were measured before and after treatment. Symptoms, physical signs and adverse effects were observed. Results: After four weeks treatment, the clinical obvious rate and the clinical effective rate in kaishi injection group and control group were 30. 00% (9/30) and 14. 29% (4/28), 53. 33% (16/30) and 42. 86% (12/28). The clinical ineffective rate in kaishi injection group and con trol group were 16. 67% (5/309) and 42. 86% (12/28). The total clinical effective rate in kaishi injection group and control group were 83. 33% (25/30) and 57. 14% (16/28) (P<0. 05). Kaishi injection significantly decrease TB, DB, AKP, ALT and AST (P<0. 05) in chronic hepatopathy patients with jaundice, and has no obvious effect on ALB and GLB (P>0. 05). There were on obvious adverse effects in kaishi injection group and control group. Conclosion: Kaishi injection can effectively treat jaundice in patients with chronic hepatopathy, and has no obvious adverse effects.

关 键 词：凯时注射液 治疗 慢性肝病 黄疸 

分 类 号：R259.75[医药卫生—中西医结合]