吸入糖皮质激素治疗慢性阻塞性肺疾病的研究  

Clinial study of inhaled corticosteroid in patients with chronic obstructive pulmonary disease.

作　　者：张莉娟[1] 薛旗山[2] 

机构地区：[1]河北省人民医院,石家庄050051 [2]北京航天总医院呼吸内科

出　　处：《中国综合临床》2004年第12期1093-1094,共2页Clinical Medicine of China

摘　　要：目的探讨中等剂量二丙酸氯地米松短疗程吸入治疗慢性阻塞性肺疾病稳定期患者的疗效。方法按照随机、对照、单盲的设计,将44例稳定期慢性阻塞性肺疾病患者分2组,观察组给予二丙酸氯地米松(800μg/d)与对照组给予安慰剂吸入治疗6周,观察治疗前后测定肺功能第1秒用力呼气量、用力肺活量,并记录临床症状评分及生活质量评分。结果观察组21例,临床症状改善,治疗前症状评分为(5.1±0.5)分,治疗后为(4.6±0.4)分(P<0.05);第1秒用力呼气量治疗前为(1.79±0.02)L,治疗后为(2.16±0.03)L(P<0.01);用力肺活量治疗前为(2.20±0.02)L,治疗后为(2.50±0.03)L(P<0.05),呼吸功能提高显著。对照组19例,治疗前后各项指标均无显著性差异(P>0.05)。结论短期二丙酸氯地米松吸入治疗稳定期慢性阻塞性肺疾病患者可缓解临床症状,提高肺功能和生活质量。Objective To explore the therapeutic efficacy of moderate dose inhaled corticosteroid in treating stable chronic obstructive pulmonary disease(COPD).Methods 44 stable COPD patients were randomly divided into two groups.The observation group was given BDP(800 μg/d)and the control group was given placebo for 6 week inhalation treatment.Forced expiratory volume (FEV 1) and forced vital capacity (FVC) were observed as well as the clinical symptoms and the scores of life quality.Results In observation group,the clinical symptoms of 21 patients were improved and the score was (5.1±0.5)vs(4.6±0.4)(P<0.05).FEV 1 became(2.16±0.03)from(1.79±0.02)(P<0.01) and FVC became(2.50±0.03)from(2.20±0.02)after treatment(P<0.05),but in control group,the indexes were not significantly changed after treatment(P>0.05).Conclusion Short term inhalation treatment with BDP of stable COPD may relieve clinical symptoms and improve pulmonary function and life quality.

关 键 词：慢性阻塞性肺疾病 二丙酸氯地米松 

分 类 号：R563.9[医药卫生—呼吸系统]