静脉麻醉药与脑保护受体机制  

Intravenous anesthetics and the receptor mechanism of neuroprotection

作　　者：王莉[1] 金正均[2] 杭燕南[3] 

机构地区：[1]上海交通大学第六人民医院麻醉科,上海200233 [2]上海第二医科大学基础医学院药理教研室 [3]上海第二医科大学仁济医院麻醉科

出　　处：《上海第二医科大学学报》2004年第11期978-980,共3页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：兴奋毒性可能是造成神经元死亡的“最后公路”。已知静脉麻醉药 ,如非竞争性NMDA受体拮抗剂 (氯胺酮 )和GABA受体模拟剂 (丙泊酚 )有神经保护作用 。The excitotoxicity may be the last public way by which neurons were led to death. It has been shown that intravenous anesthetics, such as non-competitive NMDA antagonists (ketamine) or GABAmimetics (propofol) have neuroprotection. The receptor mechanism of neuroprotection by intravenous anesthesia was reviewed in this essay.

关 键 词：静脉麻醉药 脑保护 受体机制 兴奋性氨基酸 

分 类 号：R614.24[医药卫生—麻醉学]