MMP-9/TIMP-1在胎膜早破孕妇胎膜组织中的表达及意义  

THE EXPRESSION OF MMP-9/TIMP-1 IN FETAL MEMBRANES IN PREGNANCY COMPLICATED WITH PREMATURE RUPTURE OF MEMBRANES

作　　者：马秀菊[1] 王伟明[1] 赵屹[1] 尹桂然[1] 杜瑞英[1] 李建业[1] 

机构地区：[1]河北医科大学第二医院妇产科,河北石家庄050000

出　　处：《河北医科大学学报》2004年第6期336-338,i009,共4页Journal of Hebei Medical University

摘　　要：目的探讨基质金属蛋白酶 (matrixmetalloproteinases ,MMP 9)及基质金属蛋白酶抑制剂 (tissueinhibitormatrixmetalloproteinases,TIMP 1)在胎膜早破患者胎膜组织中的表达及意义。方法随机选择胎膜早破孕妇 37例 ,包括 :Ⅰ组为足月胎膜早破 2 2例 ,Ⅱ组为未足月胎膜早破患者 15例。Ⅲ组为正常足月孕妇 2 5例作为对照组。采用免疫组化染色法测定胎膜组织中MMP 9及TIMP 1的水平。结果胎膜早破患者胎膜组织中MMP 9的水平明显高于正常对照组 ,具有显著性差异 (P<0 .0 1) ;胎膜早破患者胎膜组织中TIMP 1的水平与正常对照组相比 ,无明显差异 (P >0 .0 5 ) ;胎膜早破患者MMP 9/TIMP 1的比值与正常对照组相比 ,有明显差异 (P >0 .0 5 )。结论MMP 9在感染引起的胎膜早破中起关键性作用 ,MMP 9/TIMPObjectiveTo explore the expression of matrix metalloproteinases(MMP-9) and tissue inhibitor matrix metallopro-teinases(TIMP-1) in fetal membranes. MethodsThe fetal membranes were obtained from ①term premature rupture of membranes(n=22), ②preterm premature rupture of membranes(n=15), ③term pregnancy with intact membranes(n=25). The expression of MMP-9 and TIMP-1 were detected by immunohistochemistry. Results①The levels of MMP-9 in premature rupture of membranes(PROM) was significantly higher than those in control group(P< 0.05). ②There was no significant difference between PROM and control group in the expression of TIMP-1 in fetal membranes(P> 0.05). ③The ratio of MMP-9/TIMP-1in PROM was higher than that in control group(P< 0.05). ConclusionMMP-9 is a key factor in PROM induced by infection, the imbalance of MMP-9/ TIMP-1 indirectly lead to PROM.

关 键 词：胎膜 胎膜早破 基质溶解素1 

分 类 号：R714.56[医药卫生—妇产科学]