盐酸催化合成α-萘乙酸甲酯(英文)  

Catalytic Synthesis of Methyl α-Naphthylacetate by Hydrochloric Acid

作　　者：汪朝阳[1] 蒋姗姗[1] 谢小莹[1] 

机构地区：[1]华南师范大学化学系,广东广州510631

出　　处：《合成化学》2004年第6期603-605,610,共4页Chinese Journal of Synthetic Chemistry

摘　　要：以α 萘乙酸、甲醇为原料 ,以浓盐酸为催化剂 ,通过酯化反应合成了植物生长调节剂萘乙酸甲酯。通过正交设计讨论了醇酸摩尔比、催化剂用量、反应时间等因素对酯化产率的影响。在α 萘乙酸 5 0mmol,n(甲醇 )∶n(α 萘乙酸 ) =2 5 ,催化剂用量为α 萘乙酸质量的 17% ,反应时间 2 .0h ,酯化温度 65℃～ 69℃的最佳反应工艺条件下 ,产率 97.4 %。Using concentrated hydrochloric acid (HCl) as a cheap esterification catalyst, methyl α-naphthylacetate, an important plant growth regulator, was synthesized from α-naphthylacetic acid and methanol. Through orthogonal test, the factors influencing reaction yield are discussed. Under the optimum reaction conditions(molar ratio of methanol to α-naphthylacetic acid 25, mass ratio of HCl to α-naphthylacetic acid 17%, reaction time 2h) the yield was 97.4%.

关 键 词：Α-萘乙酸甲酯 浓盐酸 催化合成 Α-萘乙酸 甲醇 酯化 

分 类 号：O626.32[理学—有机化学] O625.15[理学—化学]