三联药物根除老年人幽门螺杆菌感染的疗效分析  

Analysis of the eradication effect of triple drug therapy for Helicobacter pylori infection in elderly patients

作　　者：吴本俨[1] 李园[1] 王孟薇[1] 王升[1] 

机构地区：[1]解放军总医院老年消化科,北京100853

出　　处：《中国新药杂志》2004年第11期1039-1041,共3页Chinese Journal of New Drugs

基　　金：解放军总医院院长基金(01YM12)

摘　　要：目的:总结分析质子泵抑制剂与2种抗生素联用对老年人幽门螺杆菌(Hp)感染根除疗效。方法:应用公认的抗Hp感染药物质子泵抑制剂和阿莫西林与替硝唑、甲硝唑、克拉霉素任一种,选择符合欧洲Maastricht2-2000共识报告标准,需要进行根除治疗Hp感染95例老年患者。治疗1月后行13C尿素呼气试验检测根除情况。结果:95例老年患者中,74例高于本底的δ千分差值(DOB)值≤4,13C尿素呼气试验结果为阴性,Hp根除率77.89％。1周疗程与2周疗程Hp根除率分别为76.19％,79.25％,卡方检验无明显统计学差异。结论:三联疗法治疗老年人Hp感染根除率低于以往文献报道的85％-90％。临床医生应高度重视提高Hp感染根除疗效。Objective:To summarize and analyze the eradication effect of a regimen consisting of a proton pump inhibitor and 2 antibiotics in treatment of Helicobacter pylori (Hp) infection in elderly patients. Methods: 95 elderly patients with Hp infections conformed to European Maastricht standard 2000 were enrolled into the study. They were divided to receive a triple therapy consisted of a proton pump inhibitor + amoxicillin + metroniadazole or tinidazole (group A) ,or consisted of a proton pump inhibitor + amoxicillin + clarithromycin (group B) and 13C urea breath test was performed after one month of treatment. Results:74 patients have a DOB value of < 4,13C urea breath test was negative in all the patients. The cure rate of Hp infection was 77. 89% . The eradication rate of Hp infection was 76.19% for 1 week therapy and 79.25% for 2 weeks therapy and there was no significant statistical difference between groups. Conclusion: The eradication rate of Hp infection obtained in this study is lower than that reported in literature and clinical physicians should pay highly attention to upgrade the eradication rate of Hp infections.

关 键 词：幽门螺杆菌 老年人 三联疗法 

分 类 号：R969.4[医药卫生—药理学] R574.1[医药卫生—药学]