青霉素V钾片与青霉素G注射剂联合治疗小儿呼吸道感染  

Combination of penicillin V and penicillin G for respiratory tract infection in children

作　　者：宁来忠[1] 黄榕[1] 祁伯祥[1] 杨于嘉[1] 

机构地区：[1]中南大学湘雅医院儿科,长沙410008

出　　处：《中南药学》2003年第4期237-238,共2页Central South Pharmacy

摘　　要：目的 为了减轻每天数次静脉注射青霉素给患儿带来的痛苦与不便,本研究比较了青霉素G静脉注射与青霉素V钾片联合治疗小儿急性肺炎、急性扁桃体炎的疗效。方法 完全随机将200例患儿分为青霉素V钾片治疗组(治疗组,n=97)和青霉素G注射剂常规治疗组(对照组,n=112)。治疗组青霉素1次静脉滴注(简称静滴)后加青霉素V钾片进行治疗;对照组青霉素每天2次静滴治疗。治疗组急性扁桃体炎患儿64例,肺炎患儿33例,用青霉素G每次10万～20万U·kg-1加入50～100mL生理盐水中静脉滴注,每天上午1次,然后口服青霉素V钾片每次15 mg·kg-1,每天3次;对照组急性扁桃体炎患儿68例,肺炎患儿44例,用青霉素G静脉滴注,每天2次(每次10万～20万U·kg-1),观察临床疗效。结果 治疗组与对照组对于小儿肺炎、急性扁桃体炎在退热和缓解症状、体征及炎性细胞恢复等方面的临床疗效相似。结论 青霉素G静脉滴注1次加青霉素V钾片治疗可以替代单用青霉素多次静注治疗小儿肺炎和扁桃体炎。且具有应用方便、减轻患儿疼痛等优点。OBJECTIVE To compare the effect of penicillin G injection and combination of penicillin (i injection with penicillin V tablet for respiratory tract infection in children, and to relieve the pain caused by injections several times a day for children. METHODS We randomly divided 209 pediatric patients into a control group (n= 112) and a treatment group (n = 97). Penicillin G was given twice intravenously at 100-200 KU · kg-1·d-1 for the control group, while penicillin G was given first and then followed by penicillin V (15 mg· d-1 ) taken orally for the treatment group. RESULTS The effects on the treatment group and that on the control group were similar. CONCLUSIONS Combination of Penicillin G injection with penicillin V tablet may replace penicillin alone for children because with similar efficacy the former is convenient and can relieve the children's pain.

关 键 词：青霉素V钾片 青霉素G注射剂 小儿 呼吸道感染 肺炎 扁桃体炎 

分 类 号：R725.6[医药卫生—儿科] R985[医药卫生—临床医学]