Effects　of　Intraventricular　Injection　of　Calmodulin　Antagonist　（Trifluoperazine）on　Pregnancy　in　Rats  

作　　者：杨纫姝 魏曙明 侯玉萍 

出　　处：《Journal of Reproduction and Contraception》1994年第2期270-276,共7页生殖与避孕（英文版）

摘　　要：Injection of TFP(a specific antagonist of CaM)into the lateral ventricles of the ratbrain on thefourth day of pregnancy causes marked antifertility effect in 83%of the rats(0%in the control group).Examination with the pontamone blue reaction for theimplantation elucidated that the antifertility effect was due to the blockage ofimplantation of the follicle.Injection of TFP into the lateral ventricles of the brainmarkedly reduced the concentration of CaM in hypothalamus,ovary and uterus.Serumprogesterone was also reduced.However,injection given on day 7 was ineffective to terminate the pregnancy.Injection given on certain time of pregnancy was able to reduce thecellular CaM content and to cause antifertility.This finding demonstrated that CaMplayed an important role during the course of pregnancy.Injection of TFP(a specific antagonist of CaM)into the lateral ventricles of the ratbrain on thefourth day of pregnancy causes marked antifertility effect in 83%of the rats(0%in the control group).Examination with the pontamone blue reaction for theimplantation elucidated that the antifertility effect was due to the blockage ofimplantation of the follicle.Injection of TFP into the lateral ventricles of the brainmarkedly reduced the concentration of CaM in hypothalamus,ovary and uterus.Serumprogesterone was also reduced.However,injection given on day 7 was ineffective to terminate the pregnancy.Injection given on certain time of pregnancy was able to reduce thecellular CaM content and to cause antifertility.This finding demonstrated that CaMplayed an important role during the course of pregnancy.

关 键 词：calmodulin(CaM) Trifluoroperazine(TFP) ANTIFERTILITY Lateral cerebralventricle 

分 类 号：R714[医药卫生—妇产科学]