电针治疗对兔急性颅脑损伤后氧自由基反应的影响  

Influence of electroacupuncture on oxygen free radical reaction in rabbit brain tissues after acute craniocerebral injury

作　　者：董广宇[1] 陈建良[1] 禹婷婷[2] 吕文[1] 

机构地区：[1]暨南大学医学院第二附属医院,广东省深圳市518020 [2]北京大学深圳医院,广东省深圳市518036

出　　处：《实用医学杂志》2004年第6期603-605,共3页The Journal of Practical Medicine

基　　金：深圳市科委自然科学基金资助 (基金编号 :0 2 388)

摘　　要：目的 :探讨电针治疗对急性颅脑损伤 (ACCI)后脑组织氧自由基反应的影响。方法 :48只家兔随机分为A组 (正常对照组 )、B组 (假损伤组 )、C组 (损伤组 )、D组 (电针治疗组 ) ,Feeney’s自由落体打击法建立ACCI动物模型 ,D组给予电针治疗 ,检测A、B组脑组织含水量、丙二醛 (MDA )含量、超氧化物歧化酶 (SOD)活性和C、D组不同时间点上述指标的变化。结果 :A与B组各检测指标无统计学差异 (P >0 0 5 ) ;与A、B组比较 ,C、D组脑组织含水量和MDA含量在ACCI后 3h即有显著性增加 (P <0 .0 1) ,且随时间延长递增 ,SOD活性则呈相反变化趋势 ;D组与C组各时点比较 ,上述指标变化均较轻。结论 :ACCI后脑组织自由基反应增强 ,电针治疗可通过降低脑组织氧自由基反应减轻脑水肿。Objective To investigate the influence of electroacupuncture on oxygen free radical reacton in brain tissues after acute craniocerebral injury (ACCI). Methods 48 rabbits were randomly divided into group A (normal control group), group B (sham injured group), group C (injured group) and group D (electroacupuncture treatment group). The model of ACCI was performed by free dropping weight. Animals in group D was treated by electroacupuncture after ACCI. Then the contents of brain water, malonyl-diadehyde (MDA) and activity of superoxide dismutase (SOD) were measured. Results The indexes measured had no statistic difference between group A and B (P>0.05); Compared with group A and B, contents of brain water and MDA were significantly increased at 3 hours after ACCI (P<0.01), and kept on ascending with time extended. SOD activity was remarkably decreased; Compared with group C, the changes of above indexes of group D were slighter. Conclusion Oxygen free radical reaction in rabbit brain tissues was enhanced after ACCI. Electroacupuncture can alleviate brain edema by attenuating free radical reaction.

关 键 词：电针治疗 氧自由基 急性颅脑损伤 后脑组织 脑组织含水量 反应 不同时间 击法 自由落体 论 

分 类 号：R245[医药卫生—针灸推拿学]