老年慢性气管炎患者血清及痰液白细胞介素水平的检测及其意义  

Detection of the interleukin levels in serum and sputum in old patients with chronic bronchitis and its significance

作　　者：叶锦辉[1] 林琦[1] 陈燕[1] 郑勤伟[1] 

机构地区：[1]广东省人民医院老年医学研究所,广州市510080

出　　处：《实用医学杂志》2004年第6期610-612,共3页The Journal of Practical Medicine

摘　　要：目的 :探讨老年慢性支气管炎患者血清及痰液白细胞介素水平变化及其意义。方法 :以放射免疫法测定 42例老年慢性支气管炎急性发作患者 ,3 7例老年慢性支气管炎缓解期患者以及 3 1例健康对照者血清及痰液中IL 2、IL 4、IL 6、IL 8水平 ,并对以上三组上述细胞因子水平进行统计学分析。结果 :急性组与缓解组血清与痰液中IL 4、IL 6、IL 8水平均高于正常对照组 (P <0 0 5 ) ,其中 ,急性组血清与痰液中上述细胞因子水平较对照组更高(P <0 0 5 )。但是 ,急性组与缓解组IL 2水平低于正常对照组 (P <0 0 5 ) ,其中 ,急性组较缓解组更低 (P <0 0 5 )。同时 ,直接相关分析表明 ,急性组血清IL 6与IL 8、IL 6与IL 4呈正相关关系 (P <0 0 5 ) ;痰液中IL 4、IL 6、IL 8相互间呈正相关关系 (P <0 0 5 )。结论 :IL 2、IL 4、IL 6、IL 8均参与老年慢性支气管炎的发病机制 ,在慢性气道炎症病理过程及急性发作中起着重要作用。这些指标的测定对于老年慢性支气管炎的诊断及炎症反应评估有一定的临床价值。Objective To study the changes of interleukin levels of serum and sputum in old patients with chronic bronchitis and its significance. Methods The levels of IL-12, IL- 4, IL-6, IL-8 of serum and sputum in 42 gerontal cases with chronic bronchitis in acute phase, 37 gerontal cases with chronic bronchitis in relieving phase and 31 cases of normal controls were detected by the method of radioimmunological analysis, and the levels of above cytokines in three groups were analyzed by statistic method. Results The levels of IL-4, IL-6, IL-8 of serum and sputum in acute group and relieving group were higher than these in control group (P<0.05), and acute group were higher than relieving group (P<0.05). But the levels of IL-2 of serum and sputum in acute group and relieving group were lower than those in control group (P<0.05), and acute group were lever than relieving group (P<0.05). In addition, the linear correlative analysis indicated that there were correlation between levels of IL-6 and IL-8, IL-6 and IL-4 of serum in acute group (P<0.05), also were levels of IL-4, IL-6, IL-8 of sputum in acute group (P<0.05). Conclusion IL-2, IL-4, IL-6, IL-8 were involved in pathogenesis mechanism of gerontal chronic bronchitis, and played important roles in chronic inflammatory response of airway and episode of acute phase. Detection of these cytokines would be valuable to diagnosis and assessment of inflammatory active in gerontal chronic bronchitis.

关 键 词：痰液 老年慢性支气管炎 IL-8 IL-4 IL-6 血清 急性 白细胞介素 

分 类 号：R562[医药卫生—呼吸系统]